Myozenin 1 Antibody (8): sc-136429
- Myozenin 1 Antibody (8) is a mouse monoclonal IgG1 κ Myozenin 1 antibody provided at 200 µg/ml
- raised against amino acids 154-209 of Myozenin 1 of mouse origin
- Myozenin 1 Antibody (8) is recommended for detection of Myozenin 1 of mouse, rat and human origin by WBIP
- Myozenin 1 Antibody (8) is available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Myozenin 1 Antibody (8) for WB applications. These reagents are now offered in bundles with Myozenin 1 Antibody (8) (see ordering information below).
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Myozenin 1 Antibody (8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Myozenin 1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Myozenin 1 antibody (8) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). Myozenin 1, also known as MYOZ1, Calsarcin-2, or FATZ, is a crucial intracellular binding protein that plays a significant role in linking Z-disk proteins to the sarcomere, which is essential for muscle function. This 299 amino acid nuclear protein is predominantly expressed in cardiac and skeletal muscle, with lower expression levels found in the prostate, pancreas, and heart. Myozenin 1 interacts with key Z-disk proteins such as α-actinin, Filamin 2, and PP2B (calcineurin), effectively forming a bridge between these proteins and muscle fibers. Such interaction is vital for coupling striated muscle activity to protein activation, contributing to Z-disk assembly and myofibrillogenesis. Myozenin 1 undergoes post-translational modifications, including phosphorylation, which can influence function and interactions, thereby impacting muscle development and repair processes. Given such integral role in muscle formation, mutations in the gene encoding Myozenin 1 have been linked to various muscular dystrophies and neuromuscular myopathies, highlighting importance in maintaining muscle integrity and function.
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Myozenin 1 Antibody (8) References:
- FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle. | Faulkner, G., et al. 2000. J Biol Chem. 275: 41234-42. PMID: 10984498
- Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. | Frey, N., et al. 2000. Proc Natl Acad Sci U S A. 97: 14632-7. PMID: 11114196
- Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines. | Takada, F., et al. 2001. Proc Natl Acad Sci U S A. 98: 1595-600. PMID: 11171996
- The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins. | Gontier, Y., et al. 2005. J Cell Sci. 118: 3739-49. PMID: 16076904
- Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy. | Arola, AM., et al. 2007. Mol Genet Metab. 90: 435-40. PMID: 17254821
- Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy. | Posch, MG., et al. 2007. Mol Genet Metab. 91: 207-8. PMID: 17434779
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myozenin 1 Antibody (8) | sc-136429 | 200 µg/ml | $322.00 | |||
Myozenin 1 Antibody (8): m-IgG Fc BP-HRP Bundle | sc-551148 | 200 µg Ab; 10 µg BP | $361.00 | |||
Myozenin 1 Antibody (8): m-IgGκ BP-HRP Bundle | sc-551144 | 200 µg Ab; 40 µg BP | $361.00 | |||
Myozenin 1 Antibody (8) AC | sc-136429 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Myozenin 1 Antibody (8) HRP | sc-136429 HRP | 200 µg/ml | $322.00 |