Myotrophin Antibody (E-2): sc-166673

Myotrophin Antibody (E-2) is a mouse monoclonal IgG2a antibody that detects Myotrophin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Myotrophin is a 117 amino acid protein that plays a crucial role in the differentiation of cerebellar neurons, particularly granule cells, which are essential for proper cerebellar function and motor coordination. Anti-Myotrophin antibody (E-2) is not only involved in cerebellar morphogenesis but also has significant implications in cardiac health, as Myotrophin has been associated with the induction of cardiac hypertrophy. Myotrophin′s ability to increase the transcript levels of protooncogenes, such as ANF and β-Myosin heavy chain, highlights its importance in cellular signaling pathways related to growth and stress responses. Additionally, Myotrophin is known to be upregulated in myocytes subjected to cyclic stretch or in response to inflammatory cytokines like tumor necrosis factor α (TNFα) and interleukin-1β, indicating its role in cardiac remodeling and response to stress. Myotrophin is predominantly expressed in the brain, with the highest levels found in this organ and the lowest in skeletal muscle, underscoring its specialized functions in neural and cardiac tissues. Myotrophin monoclonal antibody (E-2) is an invaluable tool for researchers studying the molecular mechanisms underlying cerebellar development and cardiac pathophysiology.

The preferred Myotrophin antibody is Myotrophin Antibody (D-3): sc-166072.