Myosin XVIIIa Antibody (H-10): sc-365328
- Myosin XVIIIa Antibody (H-10) is a mouse monoclonal IgG1 κ Myosin XVIIIa antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1656-1780 mapping within an internal region of Myosin XVIIIa of human origin
- Myosin XVIIIa Antibody (H-10) is recommended for detection of Myosin XVIIIa isoforms 1-5 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Myosin XVIIIa Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Myosin XVIIIa Antibody (H-10) for WB applications. These reagents are now offered in bundles with Myosin XVIIIa Antibody (H-10) (see ordering information below).
Myosin XVIIIa Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Myosin XVIIIa protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Myosin XVIIIa antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Myosin XVIIIa, also known as MYO18A, MAJN, MYSPDZ, or surfactant protein A receptor (SPR210), plays a crucial role as a TGFβ1-induced antiapoptotic factor, essential for inhibiting cytotoxic effects of tumor necrosis factor alpha (TNFα) on mouse fibroblasts. Myosin XVIIIa is primarily localized in the endoplasmic reticulum-Golgi complex and associates with membrane ruffles and filopodia, highlighting importance in cellular motility and signaling. Myosin XVIIIa exists in two isoforms: MysPDZα, containing a KE-rich region, an N-terminal PDZ domain, and a myosin homologous head region, and MysPDZβ, lacking the KE-rich region and PDZ domain. MysPDZα shows wide expression across various tissues, while MysPDZβ appears specifically in hematopoietic tissues and cell lines, exhibiting dispersed localization in the cytoplasm. These diverse functions and localization patterns of Myosin XVIIIa underscore significance in cellular processes and potential implications in disease mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Myosin XVIIIa Antibody (H-10) References:
- Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A). | Mori, K., et al. 2003. J Biochem. 133: 405-13. PMID: 12761286
- A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling. | Cross, M., et al. 2004. Biochem J. 380: 243-53. PMID: 14969583
- Subcellular localization and dynamics of MysPDZ (Myo18A) in live mammalian cells. | Mori, K., et al. 2005. Biochem Biophys Res Commun. 326: 491-8. PMID: 15582604
- The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1. | Walz, C., et al. 2005. Leukemia. 19: 1005-9. PMID: 15800673
- The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. | Isogawa, Y., et al. 2005. Biochemistry. 44: 6190-6. PMID: 15835906
- Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A. | Yang, CH., et al. 2005. J Biol Chem. 280: 34447-57. PMID: 16087679
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myosin XVIIIa Antibody (H-10) | sc-365328 | 200 µg/ml | $316.00 | |||
Myosin XVIIIa Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-529350 | 200 µg Ab; 10 µg BP | $354.00 | |||
Myosin XVIIIa Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-522208 | 200 µg Ab, 40 µg BP | $354.00 | |||
Myosin XVIIIa Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-543472 | 200 µg Ab; 20 µg BP | $354.00 | |||
Myosin XVIIIa Antibody (H-10) AC | sc-365328 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Myosin XVIIIa Antibody (H-10) HRP | sc-365328 HRP | 200 µg/ml | $316.00 | |||
Myosin XVIIIa Antibody (H-10) FITC | sc-365328 FITC | 200 µg/ml | $330.00 | |||
Myosin XVIIIa Antibody (H-10) PE | sc-365328 PE | 200 µg/ml | $343.00 | |||
Myosin XVIIIa Antibody (H-10) Alexa Fluor® 488 | sc-365328 AF488 | 200 µg/ml | $357.00 | |||
Myosin XVIIIa Antibody (H-10) Alexa Fluor® 546 | sc-365328 AF546 | 200 µg/ml | $357.00 | |||
Myosin XVIIIa Antibody (H-10) Alexa Fluor® 594 | sc-365328 AF594 | 200 µg/ml | $357.00 | |||
Myosin XVIIIa Antibody (H-10) Alexa Fluor® 647 | sc-365328 AF647 | 200 µg/ml | $357.00 | |||
Myosin XVIIIa Antibody (H-10) Alexa Fluor® 680 | sc-365328 AF680 | 200 µg/ml | $357.00 | |||
Myosin XVIIIa Antibody (H-10) Alexa Fluor® 790 | sc-365328 AF790 | 200 µg/ml | $357.00 |