Myo-inositol oxygenase Antibody (E-9): sc-166913

Myo-inositol oxygenase Antibody (E-9) is a mouse monoclonal IgG2b antibody that detects Myo-inositol oxygenase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Myo-inositol oxygenase plays a crucial role in the metabolism of Myo-inositol, catalyzing its oxidative cleavage to D-glucuronate, which is essential for various cellular processes, including cell signaling and osmoregulation. Myo-inositol oxygenase is predominantly located in the kidneys, highlighting its importance in renal function and the potential implications of its dysregulation in conditions such as diabetic nephropathy. Myo-inositol oxygenase′s activity is facilitated by a unique Fe(II)/Fe(III) binuclear iron center, which is vital for its dioxygen-dependent catalytic mechanism. Given its significant role in metabolic pathways and association with diabetes-related complications, Myo-inositol oxygenase is a valuable target for research and therapeutic interventions. Anti-Myo-inositol oxygenase antibody (E-9) is an essential tool for studying this enzyme′s function and impact on health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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Myo-inositol oxygenase Antibody (E-9) References:

1. Molecular cloning, expression, and characterization of myo-inositol oxygenase from mouse, rat, and human kidney.  |  Arner, RJ., et al. 2004. Biochem Biophys Res Commun. 324: 1386-92. PMID: 15504367
2. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells.  |  Prabhu, KS., et al. 2005. J Biol Chem. 280: 19895-901. PMID: 15778219
3. myo-Inositol oxygenase: a radical new pathway for O(2) and C-H activation at a nonheme diiron cluster.  |  Bollinger, JM., et al. 2009. Dalton Trans. 905-14. PMID: 19173070
4. Potential role and therapeutic interests of myo-inositol in metabolic diseases.  |  Croze, ML. and Soulage, CO. 2013. Biochimie. 95: 1811-27. PMID: 23764390
5. myo-Inositol oxygenase: a novel kidney-specific biomarker of acute kidney injury?  |  Konvalinka, A. 2014. Clin Chem. 60: 708-10. PMID: 24607482
6. Molecular cloning of the myo-inositol oxygenase gene from the kidney of baboons.  |  González-Álvarez, R., et al. 2017. Biomed Rep. 7: 301-305. PMID: 29085625
7. Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.  |  Tominaga, T., et al. 2019. Am J Physiol Renal Physiol. 316: F301-F315. PMID: 30539651
8. Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.  |  Sharma, I., et al. 2020. Diabetes. 69: 1248-1263. PMID: 32169892
9. Myo-inositol oxygenase in cadmium-induced kidney injury.  |  Lu, Y. and Agarwal, A. 2022. Am J Physiol Renal Physiol. 322: F470-F472. PMID: 35285275
10. Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.  |  Zhou, W., et al. 2023. Immun Inflamm Dis. 11: e829. PMID: 37249295

The preferred Myo-inositol oxygenase antibody is Myo-inositol oxygenase Antibody (E-11): sc-376080.