MYH7 Antibody (A4.951): sc-53090
- MYH7 Antibody (A4.951) is a mouse monoclonal IgG1 κ, cited in 48 publications, provided at 200 µg/ml
- raised against adult skeletal muscle myosin of human origin
- Anti-MYH7 Antibody (A4.951) is recommended for detection of myosin heavy chain 7 of mouse, rat, human, rabbit and fish origin by WB, IP, IF and IHC(P)
- Anti-MYH7 Antibody (A4.951) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MYH7 Antibody (A4.951) for WB and IHC(P) applications. These reagents are now offered in bundles with MYH7 Antibody (A4.951) (see ordering information below).
MYH7 Antibody (A4.951) is a mouse monoclonal IgG1 kappa light chain antibody that detects myosin heavy chain 7 of mouse, rat, human, rabbit, and fish origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-MYH7 antibody (A4.951) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Myosin heavy chain 7 plays a crucial role in muscle contraction and is primarily found in cardiac and slow-twitch skeletal muscle, where MYH7 contributes to the generation of force and movement. The structure of myosin heavy chain 7 forms a heterohexamer with two heavy chains and two pairs of light chains, allowing for proper interaction with actin filaments. This structural arrangement enables muscle contraction efficiency and response to physiological demands. Mutations in the MYH7 gene have been linked to hypertrophic cardiomyopathy, a condition that can lead to serious heart complications, underscoring the significance of myosin heavy chain 7 in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYH7 Antibody (A4.951) References:
- Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. | Weiss, A., et al. 1999. Proc Natl Acad Sci U S A. 96: 2958-63. PMID: 10077619
- Atomic model of a myosin filament in the relaxed state. | Woodhead, JL., et al. 2005. Nature. 436: 1195-9. PMID: 16121187
- MYH7 gene mutation in myosin storage myopathy and scapulo-peroneal myopathy. | Pegoraro, E., et al. 2007. Neuromuscul Disord. 17: 321-9. PMID: 17336526
- Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe. | Edwards, YH., et al. 1985. Ann Hum Genet. 49: 101-9. PMID: 3000272
- Two different forms of beta myosin heavy chain are expressed in human striated muscle. | Jandreski, MA., et al. 1987. Hum Genet. 77: 127-31. PMID: 3653886
- Cardiomyocyte apoptosis contributes to contractile dysfunction in stem cell model of MYH7 E848G hypertrophic cardiomyopathy. | Loiben, AM., et al. 2023. bioRxiv.. PMID: 36747800
- Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration. | Lee, S., et al. 2023. bioRxiv.. PMID: 37333118
- Isolation and characterization of human myosin heavy chain genes. | Leinwand, LA., et al. 1983. Proc Natl Acad Sci U S A. 80: 3716-20. PMID: 6304733
- Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. | Leinwand, LA., et al. 1983. Science. 221: 766-9. PMID: 6879174
- Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle. | Smerdu, V., et al. 1994. Am J Physiol. 267: C1723-8. PMID: 7545970
- Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle. | Hughes, SM., et al. 1993. Dev Biol. 158: 183-99. PMID: 7687223
- Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome. | Soussi-Yanicostas, N., et al. 1993. Hum Mol Genet. 2: 563-9. PMID: 8518795
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYH7 Antibody (A4.951) | sc-53090 | 200 µg/ml | $322.00 | |||
MYH7 Antibody (A4.951): m-IgG Fc BP-HRP Bundle | sc-528547 | 200 µg Ab; 10 µg BP | $361.00 | |||
MYH7 Antibody (A4.951): m-IgGκ BP-HRP Bundle | sc-520945 | 200 µg Ab, 40 µg BP | $361.00 | |||
MYH7 Antibody (A4.951): m-IgG1 BP-HRP Bundle | sc-542987 | 200 µg Ab; 20 µg BP | $361.00 | |||
MYH7 Antibody (A4.951) AC | sc-53090 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MYH7 Antibody (A4.951) HRP | sc-53090 HRP | 200 µg/ml | $322.00 | |||
MYH7 Antibody (A4.951) FITC | sc-53090 FITC | 200 µg/ml | $336.00 | |||
MYH7 Antibody (A4.951) PE | sc-53090 PE | 200 µg/ml | $349.00 | |||
MYH7 Antibody (A4.951) Alexa Fluor® 488 | sc-53090 AF488 | 200 µg/ml | $364.00 | |||
MYH7 Antibody (A4.951) Alexa Fluor® 546 | sc-53090 AF546 | 200 µg/ml | $364.00 | |||
MYH7 Antibody (A4.951) Alexa Fluor® 594 | sc-53090 AF594 | 200 µg/ml | $364.00 | |||
MYH7 Antibody (A4.951) Alexa Fluor® 647 | sc-53090 AF647 | 200 µg/ml | $364.00 | |||
MYH7 Antibody (A4.951) Alexa Fluor® 680 | sc-53090 AF680 | 200 µg/ml | $364.00 | |||
MYH7 Antibody (A4.951) Alexa Fluor® 790 | sc-53090 AF790 | 200 µg/ml | $364.00 |