Myosin-2/MYH2 Antibody (6D596): sc-71631

MYH2 Antibody (6D596) is a mouse monoclonal IgG1 kappa light chain antibody specifically designed to detect MYH2, also known as myosin heavy chain 2, MyHC-IIa, or fast-twitch myosin heavy chain IIa, in mouse, rat, human, and rabbit tissues. MYH2 monoclonal antibody (6D596) targets adult skeletal muscle myosin of human origin and is validated for use in western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications, ensuring reliable performance across a range of experimental techniques. MYH2 is a critical component of sarcomeric thick filaments in skeletal muscle fibers, particularly in fast-twitch (type IIa) muscle fibers, where MYH2 plays an essential role in muscle contraction by interacting with actin filaments to generate force necessary for rapid movements. Located within the A-band of the sarcomere, MYH2′s precise positioning is crucial for the sliding filament mechanism, allowing efficient cross-bridge cycling with actin in thin filaments during contraction. MYH2′s cellular localization directly influences speed and strength of muscle contraction, affecting muscle performance and adaptability. Understanding MYH2 distribution and function is vital for studying muscle physiology, fiber-type composition, and various muscle-related diseases such as myopathies and muscular dystrophies. Anti-MYH2 antibody (6D596) aids researchers in investigating molecular mechanisms underlying muscle function, adaptation, and pathology.

The preferred antibody is Antibody (): sc-32732m.