MYH15 Antibody (C-8): sc-515748
- MYH15 Antibody (C-8) is a mouse monoclonal IgG1 κ MYH15 antibody provided at 200 µg/ml
- raised against amino acids 1068-1136 mapping within an internal region of MYH15 of human origin
- MYH15 Antibody (C-8) is recommended for detection of MYH15 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MYH15 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MYH15 Antibody (C-8) for WB applications. These reagents are now offered in bundles with MYH15 Antibody (C-8) (see ordering information below).
MYH15 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects MYH15 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MYH15 (C-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MYH15, also known as Myosin heavy chain 15, is a crucial component of the cytoskeletal system, consisting of 1,946 amino acids and featuring an N-terminal myosin head-like domain and an IQ domain. MYH15 plays a significant role in muscle contractions, as MYH15 interacts with actin filaments to facilitate various cellular movements, including cytokinesis and phagocytosis. The gene encoding MYH15 is located on human chromosome 3, which is rich in genes associated with diverse biological functions, including a cluster of chemokine receptor genes and several loci related to human cancers. Understanding the structure and function of MYH15 is vital, as MYH15 is a major determinant of the speed of contraction in skeletal muscle, with different isoforms being expressed based on the muscle′s functional activity. Studying MYH15 through applications such as western blotting (WB) and immunofluorescence (IF) allows researchers to explore MYH15′s role in muscle physiology and potential implications in muscle-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYH15 Antibody (C-8) References:
- Organization of the human skeletal myosin heavy chain gene cluster. | Yoon, SJ., et al. 1992. Proc Natl Acad Sci U S A. 89: 12078-82. PMID: 1465443
- Identification of three developmentally controlled isoforms of human myosin heavy chains. | Bober, E., et al. 1990. Eur J Biochem. 189: 55-65. PMID: 1691980
- Gene variants associated with ischemic stroke: the cardiovascular health study. | Luke, MM., et al. 2009. Stroke. 40: 363-8. PMID: 19023099
- Generation of a full-length human perinatal myosin heavy-chain-encoding cDNA. | Karsch-Mizrachi, I., et al. 1990. Gene. 89: 289-94. PMID: 2373371
- Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis. | Nagai, R., et al. 1989. J Biol Chem. 264: 9734-7. PMID: 2722872
- Rare variants in MYH15 modify amyotrophic lateral sclerosis risk. | Kim, H., et al. 2019. Hum Mol Genet. 28: 2309-2318. PMID: 30985904
- TGFβ-induced cytoskeletal remodeling mediates elevation of cell stiffness and invasiveness in NSCLC. | Gladilin, E., et al. 2019. Sci Rep. 9: 7667. PMID: 31113982
- MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor. | Wang, Y., et al. 2023. BMC Cancer. 23: 959. PMID: 37817112
- Characterization of a human perinatal myosin heavy-chain transcript. | Jullian, EH., et al. 1995. Eur J Biochem. 230: 1001-6. PMID: 7601129
- Regulation of differentiation of vascular smooth muscle cells. | Owens, GK. 1995. Physiol Rev. 75: 487-517. PMID: 7624392
- Phylogenetic analysis of the myosin superfamily. | Cheney, RE., et al. 1993. Cell Motil Cytoskeleton. 24: 215-23. PMID: 8477454
- The mammalian myosin heavy chain gene family. | Weiss, A. and Leinwand, LA. 1996. Annu Rev Cell Dev Biol. 12: 417-39. PMID: 8970733
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYH15 Antibody (C-8) | sc-515748 | 200 µg/ml | $316.00 | |||
MYH15 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-531495 | 200 µg Ab; 10 µg BP | $354.00 | |||
MYH15 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-525194 | 200 µg Ab, 40 µg BP | $354.00 | |||
MYH15 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-544590 | 200 µg Ab; 20 µg BP | $354.00 | |||
MYH15 Antibody (C-8) AC | sc-515748 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MYH15 Antibody (C-8) HRP | sc-515748 HRP | 200 µg/ml | $316.00 | |||
MYH15 Antibody (C-8) FITC | sc-515748 FITC | 200 µg/ml | $330.00 | |||
MYH15 Antibody (C-8) PE | sc-515748 PE | 200 µg/ml | $343.00 | |||
MYH15 Antibody (C-8) Alexa Fluor® 488 | sc-515748 AF488 | 200 µg/ml | $357.00 | |||
MYH15 Antibody (C-8) Alexa Fluor® 546 | sc-515748 AF546 | 200 µg/ml | $357.00 | |||
MYH15 Antibody (C-8) Alexa Fluor® 594 | sc-515748 AF594 | 200 µg/ml | $357.00 | |||
MYH15 Antibody (C-8) Alexa Fluor® 647 | sc-515748 AF647 | 200 µg/ml | $357.00 | |||
MYH15 Antibody (C-8) Alexa Fluor® 680 | sc-515748 AF680 | 200 µg/ml | $357.00 | |||
MYH15 Antibody (C-8) Alexa Fluor® 790 | sc-515748 AF790 | 200 µg/ml | $357.00 |