MYH10 Antibody (3H2): sc-33729
- MYH10 Antibody (3H2) is a mouse monoclonal IgG2b MYH10 antibody, cited in 7 publications, provided at 100 µl ascites
- raised against amino acids 1964-1976 of purified myosin heavy chain of human origin
- recommended for detection of myosin heavy chains encoded by MYH10 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MYH10 Antibody (3H2). This work is in progress.
MYH10 Antibody (3H2) is a mouse monoclonal IgG2b antibody that detects MYH10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-MYH10 antibody (3H2) is available as a non-conjugated format. MYH10 protein, also known as Myosin IIb, plays a crucial role in cellular motility and muscle contraction by interacting with actin filaments to generate force. This interaction is vital for various cellular processes, including cell division, migration, and maintenance of cell shape. MYH10 protein is predominantly located in the cytoplasm, where MYH10 forms part of the cytoskeletal structure, enabling cells to respond to mechanical stimuli and maintain integrity. Additionally, MYH10 protein is involved in regulation of cellular activities through ATPase activity, which is essential for converting chemical energy into mechanical work. MYH10 protein′s structure, characterized by hexameric composition of heavy and light chains, is fundamental to function, as MYH10 allows for precise regulation of muscle contraction and cellular movements. Understanding MYH10 dynamics and interactions with other proteins is critical for elucidating mechanisms underlying muscle physiology and various pathologies associated with myosin dysfunction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYH10 Antibody (3H2) References:
- Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development. | Lu, BD., et al. 1999. Dev Biol. 216: 312-26. PMID: 10588881
- Identification of three developmentally controlled isoforms of human myosin heavy chains. | Bober, E., et al. 1990. Eur J Biochem. 189: 55-65. PMID: 1691980
- Generation of a full-length human perinatal myosin heavy-chain-encoding cDNA. | Karsch-Mizrachi, I., et al. 1990. Gene. 89: 289-94. PMID: 2373371
- Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis. | Nagai, R., et al. 1989. J Biol Chem. 264: 9734-7. PMID: 2722872
- Heterozygous variants in MYH10 associated with neurodevelopmental disorders and congenital anomalies with evidence for primary cilia-dependent defects in Hedgehog signaling. | Holtz, AM., et al. 2022. Genet Med. 24: 2065-2078. PMID: 35980381
- MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance. | Liu, L., et al. 2023. Adv Sci (Weinh). 10: e2203423. PMID: 36929633
- MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM). | García-Quintáns, N., et al. 2023. Nat Commun. 14: 6461. PMID: 37833253
- Characterization of a human perinatal myosin heavy-chain transcript. | Jullian, EH., et al. 1995. Eur J Biochem. 230: 1001-6. PMID: 7601129
- Regulation of differentiation of vascular smooth muscle cells. | Owens, GK. 1995. Physiol Rev. 75: 487-517. PMID: 7624392
- Phylogenetic analysis of the myosin superfamily. | Cheney, RE., et al. 1993. Cell Motil Cytoskeleton. 24: 215-23. PMID: 8477454
- Mechanisms of smooth muscle contraction. | Horowitz, A., et al. 1996. Physiol Rev. 76: 967-1003. PMID: 8874491
- The mammalian myosin heavy chain gene family. | Weiss, A. and Leinwand, LA. 1996. Annu Rev Cell Dev Biol. 12: 417-39. PMID: 8970733
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYH10 Antibody (3H2) | sc-33729 | 100 µl ascites | $322.00 |