MYH10 Activators
MYH10 activators are a class of molecules that play a critical role in regulating cellular processes related to cell motility, adhesion, and cytoskeletal dynamics. The term "MYH10" refers to a specific protein known as non-muscle myosin heavy chain IIB, which is a member of the myosin superfamily. Myosins are motor proteins that interact with actin filaments to generate contractile forces within cells, facilitating various cellular functions.
MYH10 activators are substances or mechanisms that enhance the activity of the MYH10 protein within cells. MYH10 is involved in actin-myosin-based contractility, and its activation is essential for processes like cell migration, cell adhesion, and tissue morphogenesis. These activators may work by promoting the phosphorylation of MYH10 or modulating its interaction with other cellular components, such as actin filaments or regulatory proteins. This regulation of MYH10 activity is crucial for the proper functioning of cells in processes like wound healing, tissue remodeling, and embryonic development. MYH10 activators contribute to the fine-tuning of cell motility and adhesion, ensuring that cells can respond appropriately to their microenvironment and carry out their functions effectively. In summary, MYH10 activators are integral components in the complex cellular machinery that governs cell motility and adhesion, playing a pivotal role in various physiological processes that rely on dynamic cell behaviors and cytoskeletal dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is an anthracycline drug used to treat various cancers. As a DNA intercalating agent, it induces DNA damage and oxidative stress. MYH10 participates in repairing such lesions, so doxorubicin exposure may increase MYH10 expression through activation of DNA damage response pathways. | ||||||
Acrylamide Solution, 40% | 79-06-1 | sc-3721 | 1 L | $100.00 | ||
Acrylamide causes oxidative stress and toxicity. As a myosin, MYH10 is involved in counteracting reactive oxygen species and maintaining cytoskeletal integrity. MYH10 levels could rise in response to the inflammatory and stress signals triggered by acrylamide. | ||||||
Arsenic sponge | 7440-38-2 | sc-278710 | 25 g | $236.00 | ||
Arsenic mediates genotoxic and epigenetic effects leading to cancers. MYH10 functions in DNA repair and chromatin remodeling. It may become transcriptionally elevated during arsenic-induced DNA damage and altered methylation to help restore cellular homeostasis. | ||||||
FCM Fixation buffer (10X) | sc-3622 | 10 ml @ 10X | $62.00 | 16 | ||
This solution induces cytotoxicity partly through formation of DNA-protein crosslinks. MYH10 assists in resolving such lesions and could see upregulated expression initiated by DNA damage signaling cascades activated as a result of formaldehyde-DNA adducts. | ||||||
Benzo[a]pyrene | 50-32-8 | sc-257130 | 1 g | $612.00 | 4 | |
Benzo[a]pyrene triggers DNA adduct formation. Increased MYH10 levels may aid in repair of benzo[a]pyrene-caused bulky DNA modifications and maintenance of architectural integrity of interphase chromosomes and spindle fibers that MYH10 aids in formation of. | ||||||