Myelin P2 Antibody (B-11): sc-374058
- Myelin P2 Antibody (B-11) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 18-56 mapping near the N-terminus of Myelin P2 of human origin
- recommended for detection of Myelin P2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Myelin P2 Antibody (B-11). This work is in progress.
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Myelin P2 Antibody (B-11) is a mouse monoclonal IgG2a antibody that detects Myelin P2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Myelin P2, also known as Peripheral Myelin protein-2, is a crucial component of peripheral myelin, playing a significant role in the organization and maintenance of myelin sheaths in the nervous system. Myelin P2 is primarily expressed in myelin-producing cells of both the central and peripheral nervous systems, where Myelin P2 is believed to facilitate the transport of fatty acids and the metabolism of myelin lipids, thereby contributing to the integrity and functionality of myelin. The unique structure of Myelin P2, which shares similarities with fatty acid binding proteins found in other tissues, underscores its specialized role in the nervous system, as Myelin P2 expression is restricted to neural tissues. Additionally, the gene encoding Myelin P2 is located on chromosome 8q21.3-q22.1 and features a TA-rich element in its 5-prime flanking region, which is essential for transcriptional regulation. Myelin P2 antibody (B-11) is an invaluable tool for researchers investigating myelin-related disorders and the underlying mechanisms of peripheral nerve function.
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Myelin P2 Antibody (B-11) References:
- Structure of myelin P2 protein from equine spinal cord. | Hunter, DJ., et al. 2005. Acta Crystallogr D Biol Crystallogr. 61: 1067-71. PMID: 16041071
- Cellular hypersensitivity to basic myelin (P2) protein in the Guillain-Barré syndrome. | Sheremata, W., et al. 1975. Can J Neurol Sci. 2: 87-90. PMID: 165869
- The secondary structure of myelin P2 protein derived by secondary structure prediction methods, circular dichroism, and 400-MHz 1H-NMR spectroscopy: implications for tertiary structure. | Shin, HC. and McFarlane, EF. 1987. Biochim Biophys Acta. 913: 155-62. PMID: 2439123
- The role of myelin P2 protein in the production of experimental allergic neuritis. | Rostami, A., et al. 1984. Ann Neurol. 16: 680-5. PMID: 6084458
- Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. | Bernlohr, DA., et al. 1984. Proc Natl Acad Sci U S A. 81: 5468-72. PMID: 6206497
- Partial structure and mapping of the human myelin P2 protein gene. | Narayanan, V., et al. 1994. J Neurochem. 63: 2010-3. PMID: 7525873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Myelin P2 Antibody (B-11) | sc-374058 | 200 µg/ml | $322.00 |