Mucin 5B/MUC5B Antibody (4H310): sc-71622

Mucin 5B Antibody (4H310) is a mouse monoclonal IgG1 antibody that detects Mucin 5B (MUC5B) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). MUC5B antibody (4H310) recognizes a high molecular weight glycoprotein essential for forming protective mucus layers in various tissues, particularly in respiratory and gastrointestinal tracts. MUC5B (4H310) monoclonal antibody helps identify proteins that trap pathogens and particulate matter, serving as a first line of defense against infections and maintaining mucosal integrity. MUC5B is predominantly expressed in gallbladder and colon, with expression significantly upregulated during chronic inflammation, highlighting MUC5B′s importance in pathological conditions such as chronic otitis media and gastric cancer. Retinoic acid regulates MUC5B through retinoid acid receptors, demonstrating the connection between vitamin A metabolism and mucin production. Abnormal MUC5B expression in gastric carcinomatous tissues suggests potential use as a biomarker for cancer progression, making anti-MUC5B antibody (4H310) valuable for studying mucin biology and disease implications.

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Mucin 5B/MUC5B Antibody (4H310) References:

1. Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate.  |  Yuan-Chen Wu, D., et al. 2007. Am J Pathol. 170: 20-32. PMID: 17200179
2. HSP70 and mucin 5B: novel protein targets of N,N'-dinitrosopiperazine-induced nasopharyngeal tumorigenesis.  |  Tang, FQ., et al. 2009. Cancer Sci. 100: 216-24. PMID: 19068094
3. Studies on bovine cervical mucin. I. The amino acid composition and N-terminal amino acid of bovine oestrus cervical mucin.  |  Bhushana Rao, KS., et al. 1973. Biochim Biophys Acta. 317: 286-302. PMID: 19999714
4. Mucin 5B promoter polymorphism is associated with susceptibility to interstitial lung diseases in Chinese males.  |  Wang, C., et al. 2014. PLoS One. 9: e104919. PMID: 25121989
5. Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma.  |  Espinoza, JA., et al. 2019. Histopathology. 74: 597-607. PMID: 30565710
6. Effects of environmental temperature on saliva flow rate and secretion of protein, amylase and mucin 5B.  |  Ligtenberg, AJM., et al. 2020. Arch Oral Biol. 109: 104593. PMID: 31710967
7. Quantitation of human cervical mucin during consecutive days and hourly during one day at midcycle.  |  Fleetwood, L., et al. 1986. Gynecol Obstet Invest. 22: 145-52. PMID: 3781345
8. Structural characterization of neutral oligosaccharides of human midcycle cervical mucin.  |  Yurewicz, EC., et al. 1982. J Biol Chem. 257: 2314-22. PMID: 6277894
9. Terminal glycosylation in human cervical mucin.  |  Chantler, EN. and Scudder, PR. 1984. Ciba Found Symp. 109: 180-95. PMID: 6569836
10. Purification of human midcycle cervical mucin and characterization of its oligosaccharides with respect to size, composition, and microheterogeneity.  |  Yurewicz, EC. and Moghissi, KS. 1981. J Biol Chem. 256: 11895-904. PMID: 6795195

The preferred Mucin 5B/MUC5B antibody is Mucin 5B/MUC5B Antibody (5B#19-2E): sc-21768.