Mucin 5AC/MUC5AC Antibody (2Q445): sc-71621
- Mucin 5AC/MUC5AC Antibody (2Q445) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against a synthetic peptide of Mucin 5AC of human origin
- recommended for detection of Mucin 5AC of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Mucin 5AC/MUC5AC (45M1): sc-21701 for Mucin 5AC/MUC5AC antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Mucin 5AC/MUC5AC Antibody (2Q445) for WB and IHC(P) applications. These reagents are now offered in bundles with Mucin 5AC/MUC5AC Antibody (2Q445) (see ordering information below).
Mucin 5AC Antibody (2Q445) is a mouse monoclonal IgG1 antibody that detects Mucin 5AC in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Mucin 5AC is a gel-forming mucin primarily secreted by surface mucous cells, playing a crucial role in the protection and lubrication of epithelial surfaces. Anti-Mucin 5AC antibody (2Q445) recognizes a structure characterized by a high molecular weight and a complex arrangement of O-linked carbohydrates, essential for forming a protective mucus barrier in the respiratory and gastrointestinal tracts. The presence of Mucin 5AC is particularly important in chronic inflammatory conditions, as pro-inflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha significantly enhance secretion, contributing to mucus overproduction often observed in diseases like asthma. Expression of Mucin 5AC is tightly regulated by various factors, including glucocorticoids, which are necessary for mRNA transcription, and retinoic acid, which modulates mucin gene expression through specific nuclear receptors. Mucin 5AC monoclonal antibody (2Q445) serves as an invaluable tool for researchers studying mucin biology and its implications in health and disease, providing insights into the mechanisms underlying mucosal immunity and inflammation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 5AC/MUC5AC Antibody (2Q445) | sc-71621 | 200 µg/ml | $322.00 | |||
Mucin 5AC/MUC5AC Antibody (2Q445): m-IgG Fc BP-HRP Bundle | sc-539378 | 200 µg Ab; 10 µg BP | $361.00 | |||
Mucin 5AC/MUC5AC Antibody (2Q445): m-IgG1 BP-HRP Bundle | sc-541446 | 200 µg Ab; 20 µg BP | $361.00 |