Mucin 16/MUC16 Antibody (X306): sc-52095
- Mucin 16/MUC16 Antibody (X306) is a mouse monoclonal IgG1, cited in 10 publications, provided at 100 µg/ml
- raised against Mucin 16 purified from human ovarian carcinoma
- recommended for detection of epitope specificity group A of Mucin 16 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mucin 16/MUC16 Antibody (X306). This work is in progress.
Mucin 16 Antibody (X306) is a mouse monoclonal IgG1 antibody that detects Mucin 16 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Mucin 16, also known as CA125, is a high molecular weight glycoprotein encoded by the MUC16 gene and is primarily located on the cell surface of epithelial tissues, particularly in the ovaries. Mucin 16′s presence in the glycocalyx plays a critical role in protecting mucosal surfaces from pathogens and particulate matter, while also facilitating cell signaling and adhesion. Mucin 16′s structure is characterized by three distinct domains: a carboxy terminal domain, an extracellular domain, and an amino terminal domain, which contribute to Mucin 16′s function as a tumor-associated antigen. Mucin 16 is particularly significant in the context of ovarian cancer, where anti-Mucin 16 antibody (X306) serves as a biomarker for disease progression and response to therapy. Mucin 16′s ability to interact with various signaling molecules and immune cells underscores Mucin 16′s importance in both tumor biology and potential therapeutic strategies, making anti-Mucin 16 antibody (X306) an invaluable tool for researchers studying cancer and epithelial cell biology.
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Mucin 16/MUC16 Antibody (X306) References:
- Quantification of MUCIN 1, cell surface associated and MUCIN16, cell surface associated proteins in tears and conjunctival epithelial cells collected from postmenopausal women. | Srinivasan, S., et al. 2013. Mol Vis. 19: 970-9. PMID: 23687433
- MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress. | Felder, M., et al. 2014. Mol Cancer. 13: 129. PMID: 24886523
- Membrane-type I matrix metalloproteinase-dependent ectodomain shedding of mucin16/ CA-125 on ovarian cancer cells modulates adhesion and invasion of peritoneal mesothelium. | Bruney, L., et al. 2014. Biol Chem. 395: 1221-31. PMID: 25205731
- Matrix-Metalloprotease Resistant Mucin-16 (MUC16) Peptide Mutants Represent a Worse Lung Adenocarcinoma Outcome. | Patel, JS., et al. 2019. Proteomics Clin Appl. 13: e1800155. PMID: 30790454
- A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer. | Crawford, A., et al. 2019. Sci Transl Med. 11: PMID: 31217340
- Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer. | Zhang, M., et al. 2021. Biochim Biophys Acta Rev Cancer. 1875: 188503. PMID: 33421585
- Detection of cancer biomarkers CA125 and CA199 via terahertz metasurface immunosensor. | Lin, S., et al. 2022. Talanta. 248: 123628. PMID: 35660997
- The Potential Role of MUC16 (CA125) Biomarker in Lung Cancer: A Magic Biomarker but with Adversity. | Saad, HM., et al. 2022. Diagnostics (Basel). 12: PMID: 36552994
- Chimeric antibody targeting unique epitope on onco-mucin16 reduces tumor burden in pancreatic and lung malignancies. | Shah, A., et al. 2023. NPJ Precis Oncol. 7: 74. PMID: 37567918
- The inflammatory markers combined with CA125 may predict postoperative survival in endometrial cancer. | Lin, H., et al. 2024. J Obstet Gynaecol. 44: 2373937. PMID: 38973690
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mucin 16/MUC16 Antibody (X306) | sc-52095 | 100 µg/ml | $316.00 |