Mucin 1/MUC1 Antibody (VU4H5): sc-7313

Mucin 1 Antibody (VU4H5) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mucin 1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Mucin 1 antibody (VU4H5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mucin 1, also known as CD227, is a type I membrane protein that plays a crucial role in cell signaling and adhesion, particularly in epithelial tissues. Aberrant expression of Mucin 1 is often associated with various epithelial tumors, including breast carcinomas, making Mucin 1 a significant marker for cancer research and diagnostics. Mucin 1′s structure features a highly glycosylated extracellular domain, which is essential for protecting epithelial cells and facilitating cell-cell interactions. Glycosylation patterns of Mucin 1 can influence interactions with other proteins, such as galectins, which are involved in cell adhesion and immune responses. Understanding these interactions helps elucidate Mucin 1′s role in tumor progression and metastasis, highlighting Mucin 1′s importance in cancer biology and potential therapeutic targeting.

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Mucin 1/MUC1 Antibody (VU4H5) References:

1. Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis.  |  González-Guerrico, AM., et al. 2002. J Biol Chem. 277: 17239-47. PMID: 11872746
2. The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region.  |  Gum, JR., et al. 1992. J Biol Chem. 267: 21375-83. PMID: 1400449
3. Mucin-1 is expressed on dendritic cells, both in vitro and in vivo.  |  Cloosen, S., et al. 2004. Int Immunol. 16: 1561-71. PMID: 15381671
4. Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells.  |  Rughetti, A., et al. 2005. J Immunol. 174: 7764-72. PMID: 15944279
5. MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications.  |  Handra-Luca, A., et al. 2005. Am J Surg Pathol. 29: 881-9. PMID: 15958852
6. The expression pattern of MUC1 glycoforms and other biomarkers of endometrial receptivity in fertile and infertile women.  |  Horne, AW., et al. 2005. Mol Reprod Dev. 72: 216-29. PMID: 15971251
7. Cloning and sequencing of a human pancreatic tumor mucin cDNA.  |  Lan, MS., et al. 1990. J Biol Chem. 265: 15294-9. PMID: 2394722
8. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.  |  Siddiqui, J., et al. 1988. Proc Natl Acad Sci U S A. 85: 2320-3. PMID: 2895474
9. Comparison of mucin-1 in human breast cancer and canine mammary gland tumor: a review study.  |  Vafaei, R., et al. 2022. Cancer Cell Int. 22: 14. PMID: 35000604
10. Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma.  |  Kumar, AR., et al. 2022. Curr Cancer Drug Targets. 22: 725-740. PMID: 35301949
11. Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.  |  Pandey, P., et al. 1995. Cancer Res. 55: 4000-3. PMID: 7664271

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mucin 1/MUC1 Antibody (VU4H5) has 106 citations in a variety of scientific publications.

Primary antibodies like Anti-Mucin 1/MUC1 Antibody (VU4H5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mucin 1/MUC1 Antibody (VU4H5) Specifications

Alternate Product Name: MUC1

Product Clone Name: VU4H5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Mucin 1

Epitope Species: human

Product Reactivity/Detection: Mucin 1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 106 citations in various scientific publications

Available Conjugates/Forms for Mucin 1/MUC1 Antibody (VU4H5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin