μ-protocadherin Antibody (G-10): sc-398841

µ-protocadherin Antibody (G-10) is a mouse monoclonal IgG1 antibody that detects µ-protocadherin in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). µ-protocadherin is a developmentally regulated, single-pass type I transmembrane protein that belongs to the cadherin superfamily, characterized by four cadherin-like ectodomains, a triply repeating mucin domain, and multiple binding regions. µ-protocadherin (G-10) antibody recognizes a protein predominantly expressed in various epithelial tissues, where µ-protocadherin localizes to the apical surface along the brush border of the proximal convoluted tubule, playing a crucial role as a calcium-dependent cell adhesion molecule that mediates cell aggregation. µ-protocadherin′s positioning at the brush border is essential for maintaining the integrity of epithelial barriers and facilitating intercellular communication. Alternative splicing results in at least four isoforms of µ-protocadherin, with variations in the mucin-like domains, which may influence functional properties and interactions with other proteins. The longest isoform uniquely contains the triply repeating mucin domain, which is thought to be significant for adhesive properties and potential involvement in signaling pathways. Anti-µ-protocadherin antibody (G-10) serves as an invaluable tool for researchers studying epithelial biology and related processes.

The preferred µ-protocadherin antibody is µ-protocadherin Antibody (A-11): sc-166953.