µ-protocadherin Antibody (A-11): sc-166953

µ-protocadherin Antibody (A-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects µ-protocadherin of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-µ-protocadherin antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. µ-protocadherin is a developmentally regulated, single-pass type I transmembrane protein that plays a crucial role in cell adhesion and signaling. µ-protocadherin (A-11) monoclonal antibody recognizes proteins primarily localized to the apical surface of epithelial tissues, particularly along the brush border of the proximal convoluted tubule, where µ-protocadherin facilitates calcium-dependent cell aggregation. This localization is vital for maintaining the integrity of epithelial barriers and regulating interactions between cells. µ-protocadherin features four cadherin-like ectodomains, a triply repeating mucin domain, and multiple binding regions, which contribute to adhesive properties and potential signaling functions. Alternative splicing results in at least four isoforms of µ-protocadherin, with variations in the mucin-like domain region, where only the longest isoform retains the triply repeating mucin domain, underscoring the complexity and functional diversity of µ-protocadherin.

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µ-protocadherin Antibody (A-11) References:

1. mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains.  |  Goldberg, M., et al. 2000. J Biol Chem. 275: 24622-9. PMID: 10801787
2. Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5.  |  Paris, MJ. and Williams, BR. 2000. Genomics. 69: 196-202. PMID: 11031102
3. Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys.  |  Goldberg, M., et al. 2002. Am J Physiol Renal Physiol. 283: F454-63. PMID: 12167596
4. Biallelic expression of HRAS and MUCDHL in human and mouse.  |  Goldberg, M., et al. 2003. Hum Genet. 112: 334-42. PMID: 12589428
5. Expression of a novel cadherin in the mouse and human intestine.  |  Moulton, DE., et al. 2004. Pediatr Res. 55: 927-34. PMID: 15028844
6. Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer.  |  Wang, Y., et al. 2004. J Clin Oncol. 22: 1564-71. PMID: 15051756
7. delta-Protocadherins: unique structures and functions.  |  Redies, C., et al. 2005. Cell Mol Life Sci. 62: 2840-52. PMID: 16261259
8. GRSDB: a database of quadruplex forming G-rich sequences in alternatively processed mammalian pre-mRNA sequences.  |  Kostadinov, R., et al. 2006. Nucleic Acids Res. 34: D119-24. PMID: 16381828
9. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon.  |  Garrison, WD., et al. 2006. Gastroenterology. 130: 1207-20. PMID: 16618389

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-µ-protocadherin Antibody (A-11) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-µ-protocadherin Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

µ-protocadherin Antibody (A-11) Specifications

Alternate Product Name: µ-protocadherin

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 126-350

Epitope Target: µ-protocadherin

Epitope Species: human

Product Reactivity/Detection: µ-protocadherin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for µ-protocadherin Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin