MTUS1 Antibody (E-8): sc-393121
- MTUS1 Antibody (E-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 836-1135 mapping near the C-terminus of MTUS1 of human origin
- MTUS1 Antibody (E-8) is recommended for detection of MTUS1 of human origin by WB, IP, IF and ELISA
- Anti-MTUS1 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MTUS1 Antibody (E-8) for WB applications. These reagents are now offered in bundles with MTUS1 Antibody (E-8) (see ordering information below).
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MTUS1 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects MTUS1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTUS1 (E-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTUS1, also known as mitochondrial tumor suppressor 1 or ATIP (angiotensin-II type 2 receptor (AT2)-interacting protein), plays a crucial role in cellular signaling and tumor suppression. MTUS1 is predominantly located in the cytoplasm and nucleus, with specific isoforms exhibiting distinct localizations; for instance, ATIP1 is found in the cytosol while ATIP4 is localized to the plasma membrane. MTUS1′s subcellular distribution enables interactions with various signaling pathways, particularly with the C-terminal tail of the AT2 receptor, which is essential for mediating the inhibition of growth factor-induced ERK 2 activation and subsequent cell proliferation. Mutations in MTUS1 have been linked to hepatocellular carcinoma, underscoring MTUS1′s role as a tumor suppressor. Five transcript variants of MTUS1 arise from alternative splicing, highlighting the complexity and regulatory potential of MTUS1 in maintaining cellular homeostasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MTUS1 Antibody (E-8) References:
- An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. | Ohi, R., et al. 2003. Dev Cell. 5: 309-21. PMID: 12919681
- Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. | Nouet, S., et al. 2004. J Biol Chem. 279: 28989-97. PMID: 15123706
- Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma. | Di Benedetto, M., et al. 2006. Mol Cell Endocrinol. 252: 207-15. PMID: 16650523
- Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP. | Di Benedetto, M., et al. 2006. Gene. 380: 127-36. PMID: 16887298
- Differential expression in normal-adenoma-carcinoma sequence suggests complex molecular carcinogenesis in colon. | Lee, S., et al. 2006. Oncol Rep. 16: 747-54. PMID: 16969489
- Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. | Li, JM., et al. 2007. Mol Endocrinol. 21: 499-511. PMID: 17068200
- Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. | Frank, B., et al. 2007. Carcinogenesis. 28: 1442-5. PMID: 17301065
- Genomic assessments of the frequent loss of heterozygosity region on 8p21.3-p22 in head and neck squamous cell carcinoma. | Ye, H., et al. 2007. Cancer Genet Cytogenet. 176: 100-6. PMID: 17656251
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTUS1 Antibody (E-8) | sc-393121 | 200 µg/ml | $316.00 | |||
MTUS1 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-527670 | 200 µg Ab; 10 µg BP | $354.00 | |||
MTUS1 Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-533043 | 200 µg Ab; 20 µg BP | $354.00 | |||
MTUS1 Antibody (E-8) AC | sc-393121 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MTUS1 Antibody (E-8) HRP | sc-393121 HRP | 200 µg/ml | $316.00 | |||
MTUS1 Antibody (E-8) FITC | sc-393121 FITC | 200 µg/ml | $330.00 | |||
MTUS1 Antibody (E-8) PE | sc-393121 PE | 200 µg/ml | $343.00 | |||
MTUS1 Antibody (E-8) Alexa Fluor® 488 | sc-393121 AF488 | 200 µg/ml | $357.00 | |||
MTUS1 Antibody (E-8) Alexa Fluor® 546 | sc-393121 AF546 | 200 µg/ml | $357.00 | |||
MTUS1 Antibody (E-8) Alexa Fluor® 594 | sc-393121 AF594 | 200 µg/ml | $357.00 | |||
MTUS1 Antibody (E-8) Alexa Fluor® 647 | sc-393121 AF647 | 200 µg/ml | $357.00 | |||
MTUS1 Antibody (E-8) Alexa Fluor® 680 | sc-393121 AF680 | 200 µg/ml | $357.00 | |||
MTUS1 Antibody (E-8) Alexa Fluor® 790 | sc-393121 AF790 | 200 µg/ml | $357.00 |