Mts1 Antibody (X9-7): sc-100784
- Mts1 Antibody (X9-7) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 100 µg/ml
- raised against recombinant Mts1 of human origin
- recommended for detection of Mts1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mts1 Antibody (X9-7). This work is in progress.
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Mts1 Antibody (X9-7) is a mouse monoclonal IgG1 antibody that detects Mts1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mts1, also known as S100A4, calvasculin, or metastasin, is a small acidic calcium-binding protein that plays a crucial role in tumor progression and metastasis, as well as significantly stimulating angiogenesis. Mts1 is primarily located in the cytoplasm and nucleus of various cell types, where Mts1 interacts with multiple signaling pathways that regulate cell growth and survival. Mts1′s presence in these cellular compartments is vital, as Mts1 modulates key processes such as apoptosis and cell migration, which are essential for cancer development and progression. Notably, Mts1 has been shown to cooperate with the tumor suppressor protein p53, binding to its C-terminal regulatory domain and inhibiting its DNA-binding activity, thereby enhancing p53-dependent apoptosis. This interaction suggests that Mts1 may contribute to the loss of p53 function in tumors, leading to a more aggressive cancer phenotype. Increasing levels of Mts1 in serum with age further indicate Mts1′s potential role in promoting tumor progression through angiogenesis stimulation. anti-Mts1 antibody (X9-7) is an invaluable tool for researchers investigating the complex mechanisms of cancer biology and the role of calcium-binding proteins in cellular processes.
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Mts1 Antibody (X9-7) References:
- The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor. | Ambartsumian, N., et al. 2001. Oncogene. 20: 4685-95. PMID: 11498791
- Mts1 regulates the assembly of nonmuscle myosin-IIA. | Li, ZH., et al. 2003. Biochemistry. 42: 14258-66. PMID: 14640694
- The Mts1/S100A4 protein is a neuroprotectant. | Pedersen, MV., et al. 2004. J Neurosci Res. 77: 777-86. PMID: 15334597
- Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. | Dempsie, Y., et al. 2011. Respir Res. 12: 159. PMID: 22185646
- Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors. | Sharapova, TN., et al. 2018. Acta Naturae. 10: 115-120. PMID: 30713770
- Mts1 Up-regulation is Associated With Aggressive Pathological Features in Thyroid Cancer. | Cheon, MG., et al. 2019. Cancer Genomics Proteomics. 16: 369-376. PMID: 31467231
- Tag7-Mts1 Complex Activates Chemotaxis of Regulatory T Cells. | Ivanova, OK., et al. 2022. Dokl Biochem Biophys. 506: 181-184. PMID: 36303048
- Modulation of mts1 expression in mouse and human normal and tumor cells. | Grigorian, M., et al. 1994. Electrophoresis. 15: 463-8. PMID: 8055872
- The mts1 gene and control of tumor metastasis. | Grigorian, MS., et al. 1993. Gene. 135: 229-38. PMID: 8276262
- S100A4 (MTS1) calcium binding protein in cancer growth, invasion and metastasis. | Sherbet, GV. and Lakshmi, MS. 1998. Anticancer Res. 18: 2415-21. PMID: 9703888
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mts1 Antibody (X9-7) | sc-100784 | 100 µg/ml | $333.00 |