Mts1 Antibody (A-7): sc-377059

Mts1 Antibody (A-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Mts1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Mts1 (A-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mts1 gene encodes a small acidic calcium-binding protein, Mts1 (also known as S100A4, calvasculin, or metastasin), which belongs to the S100 family of proteins. Mts1 primarily resides in cellular cytoplasm and nucleus, playing a crucial role in regulating cell motility, proliferation, and apoptosis. Mts1 localization becomes particularly significant in cancer, contributing to tumor progression and metastasis. Nuclear translocation of Mts1 enables interactions with various nuclear proteins, influencing gene expression and cellular stress responses. Mts1 cooperates with p53 tumor suppressor protein, enhancing p53-dependent apoptosis, potentially leading to p53 function loss in tumors and contributing to aggressive cancer phenotypes. Increasing Mts1 serum levels with age suggest a potential role in promoting tumor progression through mechanisms including angiogenesis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Mts1 Antibody (A-7) References:

1. The dimerization interface of the metastasis-associated protein S100A4 (Mts1): in vivo and in vitro studies.  |  Tarabykina, S., et al. 2001. J Biol Chem. 276: 24212-22. PMID: 11278510
2. Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction.  |  Grigorian, M., et al. 2001. J Biol Chem. 276: 22699-708. PMID: 11278647
3. The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor.  |  Ambartsumian, N., et al. 2001. Oncogene. 20: 4685-95. PMID: 11498791
4. Characterization of Sp1, AP-1, CBF and KRC binding sites and minisatellite DNA as functional elements of the metastasis-associated mts1/S100A4 gene intronic enhancer.  |  Cohn, MA., et al. 2001. Nucleic Acids Res. 29: 3335-46. PMID: 11504871
5. Transcriptional analysis of the mts1 gene with specific reference to 5' flanking sequences.  |  Tulchinsky, E., et al. 1992. Proc Natl Acad Sci U S A. 89: 9146-50. PMID: 1329089
6. Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease.  |  Lawrie, A., et al. 2005. Circ Res. 97: 227-35. PMID: 16002749
7. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension.  |  Merklinger, SL., et al. 2005. Circ Res. 97: 596-604. PMID: 16109920
8. MTS1/p16/CDKN2 lesions in primary glioblastoma multiforme.  |  Moulton, T., et al. 1995. Am J Pathol. 146: 613-9. PMID: 7887443
9. Calvasculin, as a factor affecting the microfilament assemblies in rat fibroblasts transfected by src gene.  |  Watanabe, Y., et al. 1993. FEBS Lett. 324: 51-5. PMID: 8504859
10. The S100 family of EF-hand calcium-binding proteins: functions and pathology.  |  Schäfer, BW. and Heizmann, CW. 1996. Trends Biochem Sci. 21: 134-40. PMID: 8701470
11. CDKN2 (MTS1/p16INK4A) gene alterations in hematological malignancies.  |  Uchida, T., et al. 1997. Leuk Lymphoma. 24: 449-61. PMID: 9086436
12. Effect of Mts1 on the structure and activity of nonmuscle myosin II.  |  Ford, HL., et al. 1997. Biochemistry. 36: 16321-7. PMID: 9405067

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mts1 Antibody (A-7) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Mts1 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mts1 Antibody (A-7) Specifications

Alternate Product Name: S100A4

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 44-101

Epitope Target: Mts1

Epitope Species: human

Product Reactivity/Detection: Mts1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Mts1 Antibody (A-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin