MTP Antibody (8): sc-135994

MTP Antibody (8) is a mouse monoclonal IgG2a kappa light chain antibody that detects microsomal triglyceride transfer protein (MTP) of mouse and rat origin by western blotting (WB) and immunoprecipitation (IP). Anti-MTP antibody (8) is available in a non-conjugated form, providing flexibility for various experimental needs. MTP plays a crucial role in lipid metabolism by facilitating the transport of cholesteryl esters, triglycerides, and phospholipids between phospholipid surfaces, which is essential for the proper secretion of plasma lipoproteins that contains apolipoprotein B. MTP is a heterodimer composed of MTP and protein disulfide isomerase (PDI), and MTP activity is tightly regulated by insulin and cholesterol levels, highlighting its importance in maintaining lipid homeostasis. MTP is primarily localized in the endoplasmic reticulum and is predominantly expressed in the small intestine and liver, with additional expression in the kidney, testis, and ovary, but MTP is notably absent in epithelial cells. Deficiencies in the MTP gene can lead to abetalipoproteinemia (ABL), an autosomal recessive disorder that disrupts lipoprotein metabolism, underscoring the significance of MTP in human health.

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MTP Antibody (8) References:

1. Microsomal triglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia.  |  Wang, J. and Hegele, RA. 2000. Hum Mutat. 15: 294-5. PMID: 10679949
2. Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.  |  Ohashi, K., et al. 2000. J Lipid Res. 41: 1199-204. PMID: 10946006
3. Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index.  |  Ledmyr, H., et al. 2002. J Lipid Res. 43: 51-8. PMID: 11792722
4. Hypobetalipoproteinemia with an apparently recessive inheritance due to a 'de novo' mutation of apolipoprotein B.  |  Lancellotti, S., et al. 2004. Biochim Biophys Acta. 1688: 61-7. PMID: 14732481
5. Lomitapide and Mipomersen-Inhibiting Microsomal Triglyceride Transfer Protein (MTP) and apoB100 Synthesis.  |  Blom, DJ., et al. 2019. Curr Atheroscler Rep. 21: 48. PMID: 31741187
6. Microsomal Triglyceride Transfer Protein: From Lipid Metabolism to Metabolic Diseases.  |  Iqbal, J., et al. 2020. Adv Exp Med Biol. 1276: 37-52. PMID: 32705593
7. Microsomal triglyceride transfer protein-mediated transfer of β-carotene from donor to acceptor vesicles in vitro.  |  Quadro, L., et al. 2022. Methods Enzymol. 674: 343-362. PMID: 36008012
8. Microsomal triglyceride transfer protein regulates intracellular lipolysis in adipocytes independent of its lipid transfer activity.  |  Rajan, S., et al. 2022. Metabolism. 137: 155331. PMID: 36228741
9. Microsomal triglyceride transfer protein is necessary to maintain lipid homeostasis and retinal function.  |  Grubaugh, CR., et al. 2024. FASEB J. 38: e23522. PMID: 38445789
10. The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain.  |  Shoulders, CC., et al. 1994. Nat Struct Biol. 1: 285-6. PMID: 7664034
11. Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators.  |  Hagan, DL., et al. 1994. J Biol Chem. 269: 28737-44. PMID: 7961826
12. A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triglyceride transfer protein that prevents complex formation with protein disulfide isomerase.  |  Rehberg, EF., et al. 1996. J Biol Chem. 271: 29945-52. PMID: 8939939

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MTP Antibody (8) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-MTP Antibody (8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MTP Antibody (8) Specifications

Alternate Product Name: MTP

Product Clone Name: 8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 91-288

Epitope Target: MTP

Epitope Species: mouse

Product Reactivity/Detection: MTP

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for MTP Antibody (8): N/A