MST-4 Antibody (C-11): sc-376649
- MST-4 Antibody (C-11) is a mouse monoclonal IgG1 κ MST-4 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 307-339 near the C-terminus of MST-4 of human origin
- MST-4 Antibody (C-11) is recommended for detection of MST-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-MST-4 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MST-4 Antibody (C-11) for WB applications. This reagent is now offered in a bundle with MST-4 Antibody (C-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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MST-4 Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects MST-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MST-4 (C-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MST-4, a member of the mammalian Ste20-like kinases, plays a crucial role in cellular signaling by specifically activating extracellular signal-regulated kinase (ERK), which is essential for various cellular processes such as proliferation, differentiation, and survival. This activation is particularly important in the context of placental development, immune response, and hematopoiesis, where MST-4 is highly expressed in tissues like the placenta, thymus, and peripheral blood leukocytes. MST-4′s ability to modulate ERK activity underscores its significance in maintaining cellular homeostasis and responding to extracellular signals, making MST-4 a valuable target for research in developmental biology and cancer studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MST-4 Antibody (C-11) References:
- Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. | Zhou, TH., et al. 2000. J Biol Chem. 275: 2513-9. PMID: 10644707
- Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway. | Raitt, DC., et al. 2000. EMBO J. 19: 4623-31. PMID: 10970855
- MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. | Lee, KK., et al. 2001. J Biol Chem. 276: 19276-85. PMID: 11278283
- MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. | Lin, JL., et al. 2001. Oncogene. 20: 6559-69. PMID: 11641781
- The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components. | Leberer, E., et al. 1992. EMBO J. 11: 4815-24. PMID: 1464311
- Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. | Schinkmann, K. and Blenis, J. 1997. J Biol Chem. 272: 28695-703. PMID: 9353338
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MST-4 Antibody (C-11) | sc-376649 | 200 µg/ml | $316.00 | |||
MST-4 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-523034 | 200 µg Ab, 40 µg BP | $354.00 | |||
MST-4 Antibody (C-11) AC | sc-376649 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MST-4 Antibody (C-11) HRP | sc-376649 HRP | 200 µg/ml | $316.00 | |||
MST-4 Antibody (C-11) FITC | sc-376649 FITC | 200 µg/ml | $330.00 | |||
MST-4 Antibody (C-11) PE | sc-376649 PE | 200 µg/ml | $343.00 | |||
MST-4 Antibody (C-11) Alexa Fluor® 488 | sc-376649 AF488 | 200 µg/ml | $357.00 | |||
MST-4 Antibody (C-11) Alexa Fluor® 546 | sc-376649 AF546 | 200 µg/ml | $357.00 | |||
MST-4 Antibody (C-11) Alexa Fluor® 594 | sc-376649 AF594 | 200 µg/ml | $357.00 | |||
MST-4 Antibody (C-11) Alexa Fluor® 647 | sc-376649 AF647 | 200 µg/ml | $357.00 | |||
MST-4 Antibody (C-11) Alexa Fluor® 680 | sc-376649 AF680 | 200 µg/ml | $357.00 | |||
MST-4 Antibody (C-11) Alexa Fluor® 790 | sc-376649 AF790 | 200 µg/ml | $357.00 | |||
MST-4 (C-11) Neutralizing Peptide | sc-376649 P | 100 µg/0.5 ml | $68.00 |