MST-4 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of MST-4, a protein kinase encoded by the STK26 (serine/threonine kinase 26) gene. MST-4, also known as mammalian Ste20-like kinase 4, is part of the STE20 family of serine/threonine kinases, which are involved in various signaling pathways that regulate cellular processes such as growth, differentiation, and apoptosis. MST-4 is particularly noted for its role in the regulation of cell polarity and cytoskeletal organization, as well as its involvement in signal transduction pathways that respond to cellular stress and environmental cues. By inhibiting MST-4, these compounds can disrupt its kinase activity, thereby affecting the downstream signaling pathways and cellular functions that depend on MST-4.
Structurally, MST-4 inhibitors can encompass a diverse range of molecules, including small molecules and peptides, that are specifically designed to bind to the ATP-binding site or other critical regions of the MST-4 kinase domain. These inhibitors typically act by blocking the catalytic activity of MST-4, preventing it from phosphorylating its target substrates. This inhibition can interfere with the activation of downstream effectors and the propagation of signals that rely on MST-4-mediated phosphorylation events. The study of MST-4 inhibitors is essential for understanding the intricate regulatory networks controlled by MST-4 and the broader implications of its kinase activity on cellular dynamics. Research into these inhibitors provides valuable insights into the mechanisms by which MST-4 influences cell polarity, migration, and response to stress, highlighting its significance in maintaining cellular architecture and function. By exploring the effects of MST-4 inhibition, scientists can gain a deeper understanding of the role of serine/threonine kinases in cellular signaling and the complex interplay of pathways that govern cellular behavior.
製品名 | CAS # | カタログ # | 数量 | 価格 | 引用文献 | レーティング |
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Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
STKファミリーであるプロテインキナーゼCの選択的阻害剤。 | ||||||
UCN-01 | 112953-11-4 | sc-202376 | 500 µg | $246.00 | 10 | |
スタウロスポリン誘導体であり、プロテインキナーゼCを阻害し、細胞周期停止を促進する。 | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
主要なSTKであるプロテインキナーゼAの強力な阻害剤。 | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
ストレス反応に関与するSTKであるp38 MAPキナーゼの特異的阻害剤。 | ||||||
GSK 690693 | 937174-76-0 | sc-363280 sc-363280A | 10 mg 50 mg | $255.00 $1071.00 | 4 | |
STKファミリーにおけるAKTアイソフォームを標的とする汎用AKT阻害剤。 | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
PI3K/AKT/mTOR経路の一部であるmTORキナーゼの選択的阻害剤。 | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $240.00 | 7 | |
強力かつ選択的なmTOR阻害剤であり、mTORC1およびmTORC2に作用する。 |