Date published: 2025-10-23

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MST-4 Inibitori

MST-4 inhibitors are a class of chemical compounds that specifically target and inhibit the activity of MST-4, a protein kinase encoded by the STK26 (serine/threonine kinase 26) gene. MST-4, also known as mammalian Ste20-like kinase 4, is part of the STE20 family of serine/threonine kinases, which are involved in various signaling pathways that regulate cellular processes such as growth, differentiation, and apoptosis. MST-4 is particularly noted for its role in the regulation of cell polarity and cytoskeletal organization, as well as its involvement in signal transduction pathways that respond to cellular stress and environmental cues. By inhibiting MST-4, these compounds can disrupt its kinase activity, thereby affecting the downstream signaling pathways and cellular functions that depend on MST-4.

Structurally, MST-4 inhibitors can encompass a diverse range of molecules, including small molecules and peptides, that are specifically designed to bind to the ATP-binding site or other critical regions of the MST-4 kinase domain. These inhibitors typically act by blocking the catalytic activity of MST-4, preventing it from phosphorylating its target substrates. This inhibition can interfere with the activation of downstream effectors and the propagation of signals that rely on MST-4-mediated phosphorylation events. The study of MST-4 inhibitors is essential for understanding the intricate regulatory networks controlled by MST-4 and the broader implications of its kinase activity on cellular dynamics. Research into these inhibitors provides valuable insights into the mechanisms by which MST-4 influences cell polarity, migration, and response to stress, highlighting its significance in maintaining cellular architecture and function. By exploring the effects of MST-4 inhibition, scientists can gain a deeper understanding of the role of serine/threonine kinases in cellular signaling and the complex interplay of pathways that govern cellular behavior.

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Nome del prodottoCAS #Codice del prodottoQuantitàPrezzoCITAZIONIValutazione

Bisindolylmaleimide I (GF 109203X)

133052-90-1sc-24003A
sc-24003
1 mg
5 mg
$103.00
$237.00
36
(1)

Inibitore selettivo della protein chinasi C, una famiglia di STK.

UCN-01

112953-11-4sc-202376
500 µg
$246.00
10
(1)

Derivato della staurosporina, inibisce la proteina chinasi C, aumenta l'arresto del ciclo cellulare.

H-89 dihydrochloride

130964-39-5sc-3537
sc-3537A
1 mg
10 mg
$92.00
$182.00
71
(2)

Potente inibitore della protein chinasi A, una STK chiave.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

Inibitore specifico della p38 MAP chinasi, una STK coinvolta nella risposta allo stress.

GSK 690693

937174-76-0sc-363280
sc-363280A
10 mg
50 mg
$255.00
$1071.00
4
(1)

Inibitore Pan-AKT mirato alle isoforme AKT della famiglia STK.

AZD8055

1009298-09-2sc-364424
sc-364424A
10 mg
50 mg
$160.00
$345.00
12
(2)

Inibitore selettivo della chinasi mTOR, parte della via PI3K/AKT/mTOR.

Torin 1

1222998-36-8sc-396760
10 mg
$240.00
7
(1)

Inibitore potente e selettivo di mTOR, agisce su mTORC1 e mTORC2.