MsrB3 Antibody (C-4): sc-514897
- MsrB3 Antibody (C-4) is a mouse monoclonal IgG2a κ MsrB3 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 101-120 within an internal region of MsrB3 of human origin
- MsrB3 Antibody (C-4) is recommended for detection of MsrB3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MsrB3 Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for MsrB3 Antibody (C-4) for WB applications. These reagents are now offered in bundles with MsrB3 Antibody (C-4) (see ordering information below).
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MsrB3 Antibody (C-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects MsrB3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MsrB3 (C-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MsrB3, also known as methionine-R-sulfoxide reductase B3, mitochondrial, is a 185 amino acid protein that plays a crucial role in cellular redox homeostasis by catalyzing the reduction of free and protein-bound methionine sulfoxide back to methionine. This function helps protect cells from oxidative stress, which can lead to cellular damage and contribute to various diseases. MsrB3 is expressed in several tissues, including the colon, bone marrow, cerebellum, spinal cord, small intestine, heart, eye lens, and kidney, and exists as two alternatively spliced isoforms in humans: MsrB3 isoform 1 (MsrB3B), which is localized to the mitochondria, and isoform 2 (MsrB3A), which is found in the endoplasmic reticulum. In mice, MsrB3 is primarily localized to the endoplasmic reticulum, and no splice variants have been characterized. The gene encoding MsrB3 is located on human chromosome 12, a region associated with various genetic disorders, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome, and trisomy 12p.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MsrB3 Antibody (C-4) References:
- [Achondrogenesis type II-hypochondrogenesis: radiological features.Case report]. | Delgado Carrasco, J., et al. 2001. An Esp Pediatr. 55: 553-7. PMID: 11730591
- A case of Kniest dysplasia with retinal detachment and the mutation analysis. | Yokoyama, T., et al. 2003. Am J Ophthalmol. 136: 1186-8. PMID: 14644246
- Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. | Kim, HY. and Gladyshev, VN. 2004. Mol Biol Cell. 15: 1055-64. PMID: 14699060
- Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. | Kim, HY. and Gladyshev, VN. 2004. Biochem Biophys Res Commun. 320: 1277-83. PMID: 15249228
- Lineage-specific gene duplication and loss in human and great ape evolution. | Fortna, A., et al. 2004. PLoS Biol. 2: E207. PMID: 15252450
- A familial case of achondrogenesis type II caused by a dominant COL2A1 mutation and 'patchy' expression in the mosaic father. | Forzano, F., et al. 2007. Am J Med Genet A. 143A: 2815-20. PMID: 17994563
- Trisomy 12p and monosomy 4p: phenotype-genotype correlation. | Benussi, DG., et al. 2009. Genet Test Mol Biomarkers. 13: 199-204. PMID: 19378504
- High resolution melting analysis for mutation detection for PTPN11 gene: applications of this method for diagnosis of Noonan syndrome. | Lo, FS., et al. 2009. Clin Chim Acta. 409: 75-7. PMID: 19737548
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MsrB3 Antibody (C-4) | sc-514897 | 200 µg/ml | $322.00 | |||
MsrB3 Antibody (C-4): m-IgG Fc BP-HRP Bundle | sc-526400 | 200 µg Ab; 10 µg BP | $361.00 | |||
MsrB3 Antibody (C-4): m-IgG2a BP-HRP Bundle | sc-546622 | 200 µg Ab; 10 µg BP | $361.00 | |||
MsrB3 Antibody (C-4) AC | sc-514897 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MsrB3 Antibody (C-4) HRP | sc-514897 HRP | 200 µg/ml | $322.00 | |||
MsrB3 Antibody (C-4) FITC | sc-514897 FITC | 200 µg/ml | $336.00 | |||
MsrB3 Antibody (C-4) PE | sc-514897 PE | 200 µg/ml | $349.00 | |||
MsrB3 Antibody (C-4) Alexa Fluor® 488 | sc-514897 AF488 | 200 µg/ml | $364.00 | |||
MsrB3 Antibody (C-4) Alexa Fluor® 546 | sc-514897 AF546 | 200 µg/ml | $364.00 | |||
MsrB3 Antibody (C-4) Alexa Fluor® 594 | sc-514897 AF594 | 200 µg/ml | $364.00 | |||
MsrB3 Antibody (C-4) Alexa Fluor® 647 | sc-514897 AF647 | 200 µg/ml | $364.00 | |||
MsrB3 Antibody (C-4) Alexa Fluor® 680 | sc-514897 AF680 | 200 µg/ml | $364.00 | |||
MsrB3 Antibody (C-4) Alexa Fluor® 790 | sc-514897 AF790 | 200 µg/ml | $364.00 | |||
MsrB3 (C-4) Neutralizing Peptide | sc-514897 P | 100 µg/0.5 ml | $69.00 |