MsrB3 Activators
MsrB3 activators are largely chemicals that either directly induce oxidative stress or disrupt cellular redox balance. Oxidative stress, characterized by an increase in reactive oxygen species (ROS) and reactive nitrogen species (RNS), damages cellular proteins, lipids, and DNA. Proteins like MsrB3, which function in repairing oxidatively damaged proteins, become crucial under these conditions. They counteract the heightened oxidative state by catalyzing the reduction of methionine sulfoxide back to methionine, ensuring the maintenance of protein functionality.
Compounds like hydrogen peroxide, rotenone, paraquat, and antimycin A are known inducers of oxidative stress. Their presence in the cellular environment directly increases ROS levels. Such an oxidative challenge often necessitates a protective response from the cell. This is where MsrB3's role becomes invaluable. As ROS levels rise, there's an increased likelihood of methionine residues in proteins becoming oxidized to methionine sulfoxide. MsrB3, being an enzyme that can repair these oxidized residues, sees an upregulation in its activity or expression. The enzyme thus assists in preserving protein structure and function against oxidative damage. In this context, the chemicals listed can be viewed as indirect activators of MsrB3, as they create a cellular environment where the protective function of MsrB3 is emphasized and becomes pivotal for cell survival.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen peroxide induces oxidative stress. Under oxidative conditions, proteins like MsrB3, which repair oxidized methionine residues, can see an upregulation in activity or expression to counteract the heightened oxidative state and maintain protein functionality. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of mitochondrial complex I, leading to an increase in reactive oxygen species (ROS). This rise in ROS can elevate the cellular demand for MsrB3 activity to restore oxidized methionine residues. | ||||||
Paraquat chloride | 1910-42-5 | sc-257968 | 250 mg | $168.00 | 7 | |
Paraquat is a herbicide that induces oxidative stress by generating superoxide radicals. The presence of such radicals can elevate the role of MsrB3 in cellular protection against oxidative damage by restoring methionine residues. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A inhibits mitochondrial complex III, resulting in enhanced ROS production. With the increased oxidative stress, proteins like MsrB3 become crucial for maintaining redox homeostasis by repairing oxidized methionines. | ||||||
tert-Butyl hydroperoxide aqueous solution | 75-91-2 | sc-251134 sc-251134A | 100 ml 500 ml | $46.00 $100.00 | 1 | |
TBHP is an organic peroxide that induces oxidative stress. Its presence can increase the need for MsrB3's protective role in reversing oxidation of methionine residues, thus aiding in cellular protection. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Menadione (vitamin K3) increases ROS levels. Elevated ROS can drive the cellular need for MsrB3 activity to counteract the oxidative state and assist in maintaining protein structure and function. | ||||||
4-Hydroxynonenal | 75899-68-2 | sc-202019 sc-202019A sc-202019B | 1 mg 10 mg 50 mg | $118.00 $655.00 $2774.00 | 25 | |
4-HNE is a lipid peroxidation product that can form protein adducts and cause oxidative stress. The consequential oxidative damage can potentially elevate the demand for MsrB3's reparative activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc can modulate cellular redox status. While at certain levels, zinc is protective against oxidative stress; its imbalances can induce oxidative conditions that may promote MsrB3 activity for protection against protein oxidation. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Sodium selenite can, at high concentrations, induce oxidative stress. This oxidative challenge might necessitate heightened activity or expression of MsrB3 to counteract protein oxidation. | ||||||