MSL3L1 Antibody (E-7): sc-518210
- MSL3L1 Antibody (E-7) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 368-388 of MSL3L1 of human origin
- recommended for detection of MSL3L1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MSL3L1 Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG3 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MSL3L1 Antibody (E-7) for WB applications. These reagents are now offered in bundles with MSL3L1 Antibody (E-7) (see ordering information below).
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MSL3L1 Antibody (E-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects MSL3L1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MSL3L1 antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MSL3L1 plays a crucial role in X-chromosome dosage compensation, a vital process that ensures equal expression of X-linked genes in both sexes, which is particularly important in species with differing sex chromosome compositions. In Drosophila, the male-specific lethal (MSL) complex, which includes MSL3L1, is essential for upregulating genes on the male X chromosome to balance gene dosage with females, who have two X chromosomes. Human MSL3L1 shares significant homology with Drosophila MSL-3, particularly in regions containing two putative chromo domains involved in chromatin recognition and regulation. MSL3L1 is located at a chromosomal site associated with several genetic disorders, including microphthalmia with linear skin defects, OFD1, SED tarda, Aicardi syndrome, and Goltz syndrome, highlighting MSL3L1′s importance in both developmental biology and clinical genetics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MSL3L1 Antibody (E-7) References:
- Characterization of a novel chromo domain gene in xp22.3 with homology to Drosophila msl-3. | Prakash, SK., et al. 1999. Genomics. 59: 77-84. PMID: 10395802
- The genome sequence of Drosophila melanogaster. | Adams, MD., et al. 2000. Science. 287: 2185-95. PMID: 10731132
- Origin and evolution of the regulatory gene male-specific lethal-3. | Marín, I. and Baker, BS. 2000. Mol Biol Evol. 17: 1240-50. PMID: 10908644
- Dosage dependent gene regulation and the compensation of the X chromosome in Drosophila males. | Birchler, JA., et al. 2003. Genetica. 117: 179-90. PMID: 12723697
- MSL proteins and the regulation of gene expression. | Rea, S. and Akhtar, A. 2006. Curr Top Microbiol Immunol. 310: 117-40. PMID: 16909909
- The right dose for every sex. | Mendjan, S. and Akhtar, A. 2007. Chromosoma. 116: 95-106. PMID: 17124606
- Mother and daughter with a terminal Xp deletion: implication of chromosomal mosaicism and X-inactivation in the high clinical variability of the microphthalmia with linear skin defects (MLS) syndrome. | Wimplinger, I., et al. 2007. Eur J Med Genet. 50: 421-31. PMID: 17845869
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MSL3L1 Antibody (E-7) | sc-518210 | 200 µg/ml | $322.00 | |||
MSL3L1 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-551185 | 200 µg Ab; 40 µg BP | $361.00 | |||
MSL3L1 Antibody (E-7): m-IgG3 BP-HRP Bundle | sc-551186 | 200 µg Ab; 40 µg BP | $361.00 | |||
MSL3L1 Antibody (E-7) AC | sc-518210 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MSL3L1 Antibody (E-7) HRP | sc-518210 HRP | 200 µg/ml | $322.00 | |||
MSL3L1 Antibody (E-7) FITC | sc-518210 FITC | 200 µg/ml | $336.00 | |||
MSL3L1 Antibody (E-7) PE | sc-518210 PE | 200 µg/ml | $349.00 | |||
MSL3L1 Antibody (E-7) Alexa Fluor® 488 | sc-518210 AF488 | 200 µg/ml | $364.00 | |||
MSL3L1 Antibody (E-7) Alexa Fluor® 546 | sc-518210 AF546 | 200 µg/ml | $364.00 | |||
MSL3L1 Antibody (E-7) Alexa Fluor® 594 | sc-518210 AF594 | 200 µg/ml | $364.00 | |||
MSL3L1 Antibody (E-7) Alexa Fluor® 647 | sc-518210 AF647 | 200 µg/ml | $364.00 | |||
MSL3L1 Antibody (E-7) Alexa Fluor® 680 | sc-518210 AF680 | 200 µg/ml | $364.00 | |||
MSL3L1 Antibody (E-7) Alexa Fluor® 790 | sc-518210 AF790 | 200 µg/ml | $364.00 |