MSK1 Antibody (F-4): sc-518173

MSK1 Antibody (F-4) is a mouse monoclonal IgM kappa antibody that detects MSK1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MSK1 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MSK1, also known as RLPK, plays a crucial role in cellular signaling pathways, particularly in response to receptor tyrosine kinase activation, which is vital for regulating various cellular processes such as growth, differentiation, and survival. One of the significant aspects of MSK1 is its ability to phosphorylate histone H3, a modification that is essential for chromatin remodeling and gene expression regulation during the cell cycle. This phosphorylation event is particularly important in the context of cellular responses to stress and mitogenic signals, highlighting MSK1′s role in mediating the effects of extracellular signals on gene expression and cellular function. The structural similarities between MSK1 and other members of the ribosomal S6 kinase family suggest that while they share common regulatory mechanisms, MSK1 may also be subject to unique regulatory pathways that further define its functional specificity in cellular signaling.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MSK1 Antibody (F-4) References:

1. MSK1 and MSK2 mediate mitogen- and stress-induced phosphorylation of histone H3: a controversy resolved.  |  Davie, JR. 2003. Sci STKE. 2003: PE33. PMID: 12915720
2. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily.  |  Kozma, SC., et al. 1990. Proc Natl Acad Sci U S A. 87: 7365-9. PMID: 1699226
3. Role of the ERK/MSK1 signalling pathway in chromatin remodelling and brain responses to drugs of abuse.  |  Brami-Cherrier, K., et al. 2009. J Neurochem. 108: 1323-35. PMID: 19183268
4. Identification of mitogen-responsive ribosomal protein S6 kinase pp90rsk, a homolog of Xenopus S6 kinase II, in chicken embryo fibroblasts.  |  Sweet, LJ., et al. 1990. Mol Cell Biol. 10: 2413-7. PMID: 2325657
5. Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase.  |  Alcorta, DA., et al. 1989. Mol Cell Biol. 9: 3850-9. PMID: 2779569
6. Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition.  |  Privitera, L., et al. 2020. J Neurosci. 40: 4644-4660. PMID: 32376781
7. Nodakenin Inhibits Melanogenesis Via the ERK/MSK1 Signaling Pathway.  |  Yoon, Y., et al. 2023. Pharmazie. 78: 6-12. PMID: 37138409
8. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.  |  Zhao, Y., et al. 1995. Mol Cell Biol. 15: 4353-63. PMID: 7623830
9. Divergent functional roles for p90rsk kinase domains.  |  Bjørbaek, C., et al. 1995. J Biol Chem. 270: 18848-52. PMID: 7642538
10. Human rsk isoforms: cloning and characterization of tissue-specific expression.  |  Moller, DE., et al. 1994. Am J Physiol. 266: C351-9. PMID: 8141249
11. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region.  |  Gout, I., et al. 1998. J Biol Chem. 273: 30061-4. PMID: 9804755
12. Cloning and characterization of RLPK, a novel RSK-related protein kinase.  |  New, L., et al. 1999. J Biol Chem. 274: 1026-32. PMID: 9873047

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MSK1 Antibody (F-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MSK1 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MSK1 Antibody (F-4) Specifications

Alternate Product Name: MSK1

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 634-656

Epitope Target: MSK1

Epitope Species: human

Product Reactivity/Detection: MSK1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MSK1 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin