MRP5 Antibody (E-4): sc-390797

MRP5 Antibody (E-4) is a mouse monoclonal IgG2b light chain antibody that detects MRP5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP5, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in the transport of various organic anions across cellular membranes, which is vital for maintaining cellular homeostasis and drug resistance in cancer cells. MRP5 is predominantly localized in the liver and kidney, where MRP5 facilitates the efflux of drugs and metabolites, thereby influencing pharmacokinetics and the efficacy of therapeutic agents. The structure of MRP5 includes multiple transmembrane domains that form a channel for substrate transport, and proper functioning is essential for detoxifying harmful compounds and regulating the levels of endogenous substances. MRP5 is known to interact with specific proteins such as glutathione, which is critical for mediating the transport of glutathione conjugates. Anti-MRP5 antibody (E-4) is an invaluable tool for researchers studying multidrug resistance mechanisms and the physiological roles of ABC transporters in various disease contexts.

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MRP5 Antibody (E-4) References:

1. Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer.  |  Oguri, T., et al. 2000. Int J Cancer. 86: 95-100. PMID: 10728601
2. Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells.  |  Wielinga, PR., et al. 2003. J Biol Chem. 278: 17664-71. PMID: 12637526
3. Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation.  |  Meyer Zu Schwabedissen, HE., et al. 2005. Am J Pathol. 166: 39-48. PMID: 15631998
4. The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.  |  Wielinga, P., et al. 2005. Cancer Res. 65: 4425-30. PMID: 15899835
5. Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP.  |  Schulz, T., et al. 2007. J Biol Chem. 282: 20999-1004. PMID: 17540771
6. Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump.  |  Meissner, K., et al. 2007. Shock. 28: 564-9. PMID: 17589384
7. Prognostic significance of MRP5 immunohistochemical expression in glioblastoma.  |  Alexiou, GA., et al. 2012. Cancer Chemother Pharmacol. 69: 1387-91. PMID: 22278731
8. Immunohistochemical study of MRP5 expression in meningiomas.  |  Alexiou, GA., et al. 2013. Cancer Chemother Pharmacol. 71: 825-8. PMID: 23271324
9. MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells.  |  Masetto, F., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118824. PMID: 32828758
10. The potential involvement of MRP5 pump in urethral dysfunction in streptozotocin-induced diabetic rats.  |  Lv, R., et al. 2023. Int Urol Nephrol. 55: 285-293. PMID: 36327005

The preferred MRP5 antibody is MRP5 Antibody (E-10): sc-376965.