MRP1 Antibody (E-7): sc-365990
- MRP1 Antibody (E-7) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1497-1531 near the C-terminus of MRP1 of human origin
- recommended for detection of MRP1 of human origin by WB, IP, IF and ELISA
- See MRP1 (QCRL-1): sc-18835 for MRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG3 BP-HRP is the preferred secondary detection reagent for MRP1 Antibody (E-7) for WB applications. This reagent is now offered in a bundle with MRP1 Antibody (E-7) (see ordering information below).
MRP1 Antibody (E-7) is a mouse monoclonal IgG3 antibody that detects MRP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP1, or multidrug-resistance protein 1, plays a crucial role in the cellular efflux of various substrates, including drugs and endogenous compounds, thereby contributing to the phenomenon of multidrug resistance in cancer cells. MRP1 is primarily located in the plasma membrane of various cell types, including those in the brain, lungs, and testis, which is significant because MRP1 expression in these tissues can influence drug pharmacokinetics and therapeutic efficacy. MRP1 presence in the blood-brain barrier can limit the effectiveness of chemotherapeutic agents, making MRP1 a critical target for research aimed at overcoming drug resistance in cancer treatment. MRP1′s structure includes an Mdr-like core and a unique N-terminal membrane-bound region, which are essential for MRP1 function as a transporter. Understanding MRP1 dynamics and interactions with other proteins can provide insights into the mechanisms of drug resistance and potential strategies for enhancing drug delivery in resistant tumors. Anti-MRP1 antibody (E-7) is an invaluable tool for researchers investigating these pathways and the broader implications of multidrug resistance in cancer therapy.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP1 Antibody (E-7) | sc-365990 | 200 µg/ml | $322.00 | |||
MRP1 Antibody (E-7): m-IgG3 BP-HRP Bundle | sc-550439 | 200 µg Ab; 40 µg BP | $361.00 | |||
MRP1 (E-7) Neutralizing Peptide | sc-365990 P | 100 µg/0.5 ml | $69.00 |