MRP-L42 Antibody (H-8): sc-515820
- MRP-L42 Antibody (H-8) is a mouse monoclonal IgG1 κ MRP-L42 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 30-46 within an internal region of MRP-L42 of human origin
- MRP-L42 Antibody (H-8) is recommended for detection of MRP-L42 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MRP-L42 Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MRP-L42 Antibody (H-8) for WB applications. These reagents are now offered in bundles with MRP-L42 Antibody (H-8) (see ordering information below).
MRP-L42 Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRP-L42 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP-L42 (H-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP-L42, also known as mitochondrial ribosomal protein L42, is a crucial component of mitochondrial ribosomes, which are essential for protein synthesis within mitochondria. This 142 amino acid protein is part of the large 39S ribosomal subunit and the small 28S ribosomal subunit, working alongside other mitochondrial ribosomal proteins to facilitate the translation of mitochondrial mRNA into functional proteins. Proper functioning of MRP-L42 is vital, as MRP-L42 plays a significant role in maintaining mitochondrial health and energy production, which is critical for cellular metabolism and overall organismal vitality. The gene encoding MRP-L42 is located on human chromosome 12, a region associated with various genetic disorders, highlighting the importance of this protein in both normal physiology and disease contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MRP-L42 Antibody (H-8) References:
- Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. | Suzuki, T., et al. 2001. J Biol Chem. 276: 21724-36. PMID: 11279069
- The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. | Cavdar Koc, E., et al. 2001. J Biol Chem. 276: 19363-74. PMID: 11279123
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. | Kenmochi, N., et al. 2001. Genomics. 77: 65-70. PMID: 11543634
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. | Koc, EC., et al. 2001. J Biol Chem. 276: 43958-69. PMID: 11551941
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
- Nuclear MRP genes and mitochondrial disease. | O'Brien, TW., et al. 2005. Gene. 354: 147-51. PMID: 15908146
- Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis. | Hao, C., et al. 2018. Biosci Rep. 38: PMID: 29531015
- Expression analysis of mammalian mitochondrial ribosomal protein genes. | Cheong, A., et al. 2020. Gene Expr Patterns. 38: 119147. PMID: 32987154
- MRPL42 is activated by YY1 to promote lung adenocarcinoma progression. | Jiang, W., et al. 2021. J Cancer. 12: 2403-2411. PMID: 33758616
- RNA-Seq and miRNA-Seq data from Epstein-Barr virus-infected tree shrews reveal a ceRNA network contributing to immune microenvironment regulation. | Xia, W., et al. 2024. Virulence. 15: 2306795. PMID: 38251668
- Decreased Mrpl42 expression exacerbates myocardial ischemia and reperfusion injury by inhibiting mitochondrial translation. | Zhang, X., et al. 2025. Cell Signal. 125: 111482. PMID: 39447668
- Mitochondrial ribosomal proteins (MRPs) of yeast. | Graack, HR. and Wittmann-Liebold, B. 1998. Biochem J. 329 (Pt 3): 433-48. PMID: 9445368
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP-L42 Antibody (H-8) | sc-515820 | 200 µg/ml | $316.00 | |||
MRP-L42 Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-531527 | 200 µg Ab; 10 µg BP | $354.00 | |||
MRP-L42 Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-525238 | 200 µg Ab, 40 µg BP | $354.00 | |||
MRP-L42 Antibody (H-8) AC | sc-515820 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MRP-L42 Antibody (H-8) HRP | sc-515820 HRP | 200 µg/ml | $316.00 | |||
MRP-L42 Antibody (H-8) FITC | sc-515820 FITC | 200 µg/ml | $330.00 | |||
MRP-L42 Antibody (H-8) PE | sc-515820 PE | 200 µg/ml | $343.00 | |||
MRP-L42 Antibody (H-8) Alexa Fluor® 488 | sc-515820 AF488 | 200 µg/ml | $357.00 | |||
MRP-L42 Antibody (H-8) Alexa Fluor® 546 | sc-515820 AF546 | 200 µg/ml | $357.00 | |||
MRP-L42 Antibody (H-8) Alexa Fluor® 594 | sc-515820 AF594 | 200 µg/ml | $357.00 | |||
MRP-L42 Antibody (H-8) Alexa Fluor® 647 | sc-515820 AF647 | 200 µg/ml | $357.00 | |||
MRP-L42 Antibody (H-8) Alexa Fluor® 680 | sc-515820 AF680 | 200 µg/ml | $357.00 | |||
MRP-L42 Antibody (H-8) Alexa Fluor® 790 | sc-515820 AF790 | 200 µg/ml | $357.00 |