MPST Antibody (H-11): sc-376168

MPST Antibody (H-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects MPST protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MPST (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MPST protein, also known as mercaptopyruvate sulfurtransferase or TST2, is a 297 amino acid enzyme that plays a crucial role in cellular detoxification processes by catalyzing the transfer of sulfur ions to thiol compounds, such as cyanide, thereby facilitating cyanide detoxification and cysteine degradation. This enzymatic function is particularly important in protecting cells from the toxic effects of cyanide exposure, which can occur in various pathological conditions. MPST exists as a monomer or as a disulfide-linked homodimer, and proper functioning is essential for maintaining cellular redox balance. Deficiency in MPST has been linked to the rare disorder mercaptolactate-cysteine disulfiduria (MCDU), highlighting MPST′s significance in metabolic pathways. The gene encoding MPST is located on human chromosome 22, which houses over 500 genes and is the second smallest human chromosome; mutations in several genes on this chromosome are implicated in various disorders, including Phelan-McDermid syndrome, Neurofibromatosis type 2, autism, and schizophrenia.

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MPST Antibody (H-11) References:

1. Evidence for a functional genetic polymorphism of the human mercaptopyruvate sulfurtransferase (MPST), a cyanide detoxification enzyme.  |  Billaut-Laden, I., et al. 2006. Toxicol Lett. 165: 101-11. PMID: 16545926
2. Microplate selection technique (MPST). A new method for selecting mouse transfectants expressing human gene products.  |  Peruzzi, L., et al. 1989. J Immunol Methods. 123: 113-21. PMID: 2507641
3. Mercaptopyruvate acts as endogenous vasodilator independently of 3-mercaptopyruvate sulfurtransferase activity.  |  Mitidieri, E., et al. 2018. Nitric Oxide. 75: 53-59. PMID: 29452248
4. Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway in cancer cells.  |  Augsburger, F. and Szabo, C. 2020. Pharmacol Res. 154: 104083. PMID: 30500457
5. 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway.  |  Zhang, F., et al. 2020. Am J Physiol Cell Physiol. 319: C720-C733. PMID: 32813542
6. Acute acrylonitrile exposure inhibits endogenous H2S biosynthesis in rat brain and liver: The role of CBS/3-MPST-H2S pathway in its astrocytic toxicity.  |  Yang, B., et al. 2021. Toxicology. 451: 152685. PMID: 33486070
7. Inhibition of the 3-mercaptopyruvate sulfurtransferase-hydrogen sulfide system promotes cellular lipid accumulation.  |  Casili, G., et al. 2022. Geroscience. 44: 2271-2289. PMID: 35680713
8. Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells.  |  Santos, SS., et al. 2023. Antioxidants (Basel). 12: PMID: 36978895
9. Protective role of 3-mercaptopyruvate sulfurtransferase (MPST) in the development of metabolic syndrome and vascular inflammation.  |  Zampas, P., et al. 2025. Pharmacol Res. 211: 107542. PMID: 39667544
10. Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.  |  Sprenger, HG., et al. 2025. Cell Metab.. PMID: 39965563

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MPST Antibody (H-11) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-MPST Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MPST Antibody (H-11) Specifications

Alternate Product Name: MPST

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 117-165

Epitope Target: MPST

Epitope Species: human

Product Reactivity/Detection: MPST

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for MPST Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred MPST antibody is MPST Antibody (D-8): sc-374326.