MOV10 Antibody (B-3): sc-515722

MOV10 Antibody (B-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects MOV10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MOV10 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MOV10, also known as Moloney leukemia virus 10, putative helicase MOV-10, gb110, or fSAP113, is a 1,003 amino acid protein that plays a crucial role in RNA metabolism and gene regulation. MOV10 is a novel telomerase-associated protein belonging to the DNA2/NAM7 helicase family and SDE3 subfamily, and MOV10 is primarily localized to mRNA-degrading cytoplasmic P bodies. This localization is significant as MOV10 functions as an RNA helicase essential for mediating microRNA-guided mRNA cleavage and facilitating RNA-mediated gene silencing through the RNA-induced silencing complex (RISC). Highly expressed in the ovary and testis, MOV10 is also implicated in the transcription and replication of the hepatitis delta virus (HDV) and interacts with several key proteins, including eIF2C1, eIF2C2, eIF6, Dicer, and TRBP2. The MOV10 gene, located on human chromosome 1 and mouse chromosome 3, produces three alternatively spliced isoforms, and post-translational modifications such as phosphorylation may occur following DNA damage, mediated by ATM or ATR, further highlighting MOV10′s importance in cellular responses to stress.

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MOV10 Antibody (B-3) References:

1. The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.  |  Baird, D., et al. 2005. Curr Biol. 15: 1-10. PMID: 15649357
2. MicroRNA silencing through RISC recruitment of eIF6.  |  Chendrimada, TP., et al. 2007. Nature. 447: 823-8. PMID: 17507929
3. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.  |  Matsuoka, S., et al. 2007. Science. 316: 1160-6. PMID: 17525332
4. Capped small RNAs and MOV10 in human hepatitis delta virus replication.  |  Haussecker, D., et al. 2008. Nat Struct Mol Biol. 15: 714-21. PMID: 18552826
5. MOV10 as a novel telomerase-associated protein.  |  Nakano, M., et al. 2009. Biochem Biophys Res Commun. 388: 328-32. PMID: 19665004
6. Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.  |  Furtak, V., et al. 2010. PLoS One. 5: e9081. PMID: 20140200
7. Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.  |  Skariah, G., et al. 2017. BMC Biol. 15: 54. PMID: 28662698
8. The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.  |  Liu, T., et al. 2019. J Biol Chem. 294: 19804-19813. PMID: 31722967
9. Unwinding the roles of RNA helicase MOV10.  |  Nawaz, A., et al. 2022. Wiley Interdiscip Rev RNA. 13: e1682. PMID: 34327836
10. MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral Activity.  |  Wang, L., et al. 2021. mBio. 12: e0131621. PMID: 34517762
11. FMRP and MOV10 regulate Dicer1 expression and dendrite development.  |  Lannom, MC., et al. 2021. PLoS One. 16: e0260005. PMID: 34847178
12. Host MOV10 is induced to restrict herpes simplex virus 1 lytic infection by promoting type I interferon response.  |  Yang, X., et al. 2022. PLoS Pathog. 18: e1010301. PMID: 35157734

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MOV10 Antibody (B-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MOV10 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MOV10 Antibody (B-3) Specifications

Alternate Product Name: MOV10

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-57

Epitope Target: MOV10

Epitope Species: human

Product Reactivity/Detection: MOV10

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MOV10 Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin