MORF4L1 Antibody (E-8): sc-514877
- MORF4L1 Antibody (E-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-51 mapping at the N-terminus of MORF4L1 of human origin
- Anti-MORF4L1 Antibody (E-8) is recommended for detection of MORF4L1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MORF4L1 Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for MORF4L1 Antibody (E-8) for WB applications. This reagent is now offered in a bundle with MORF4L1 Antibody (E-8) (see ordering information below).
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MORF4L1 Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects MORF4L1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MORF4L1 antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MORF4L1, also known as MRG15, plays a crucial role in transcription regulation, particularly through interactions with key proteins such as the retinoblastoma tumor suppressor (Rb) and PAM14, which are involved in cell cycle control and senescence. MORF4L1 associates with the histone acetyl transferase MOF, highlighting MORF4L1′s importance in chromatin remodeling and gene expression regulation. MORF4L1 is primarily localized in the dendrites and nuclei of Purkinje cells, underscoring MORF4L1′s significance in neuronal function and development. A C-terminal leucine zipper in MORF4L1, along with interactions with other members of the mortality factor family, suggests a complex network of regulatory mechanisms that may influence cellular senescence and transcriptional repression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MORF4L1 Antibody (E-8) References:
- MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14. | Leung, JK., et al. 2001. J Biol Chem. 276: 39171-8. PMID: 11500496
- A chromodomain-containing nuclear protein, MRG15 is expressed as a novel type of dendritic mRNA in neurons. | Matsuoka, Y., et al. 2002. Neurosci Res. 42: 299-308. PMID: 11985882
- Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split. | Yochum, GS. and Ayer, DE. 2002. Mol Cell Biol. 22: 7868-76. PMID: 12391155
- MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation. | Pardo, PS., et al. 2002. J Biol Chem. 277: 50860-6. PMID: 12397079
- Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes. | Bertram, MJ., et al. 1999. Mol Cell Biol. 19: 1479-85. PMID: 9891081
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MORF4L1 Antibody (E-8) | sc-514877 | 200 µg/ml | $322.00 | |||
MORF4L1 Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-526399 | 200 µg Ab; 10 µg BP | $361.00 | |||
MORF4L1 Antibody (E-8) AC | sc-514877 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MORF4L1 Antibody (E-8) HRP | sc-514877 HRP | 200 µg/ml | $322.00 | |||
MORF4L1 Antibody (E-8) FITC | sc-514877 FITC | 200 µg/ml | $336.00 | |||
MORF4L1 Antibody (E-8) PE | sc-514877 PE | 200 µg/ml | $349.00 | |||
MORF4L1 Antibody (E-8) Alexa Fluor® 488 | sc-514877 AF488 | 200 µg/ml | $364.00 | |||
MORF4L1 Antibody (E-8) Alexa Fluor® 546 | sc-514877 AF546 | 200 µg/ml | $364.00 | |||
MORF4L1 Antibody (E-8) Alexa Fluor® 594 | sc-514877 AF594 | 200 µg/ml | $364.00 | |||
MORF4L1 Antibody (E-8) Alexa Fluor® 647 | sc-514877 AF647 | 200 µg/ml | $364.00 | |||
MORF4L1 Antibody (E-8) Alexa Fluor® 680 | sc-514877 AF680 | 200 µg/ml | $364.00 | |||
MORF4L1 Antibody (E-8) Alexa Fluor® 790 | sc-514877 AF790 | 200 µg/ml | $364.00 |