Morc3 Antibody (G-12): sc-514672
- Morc3 Antibody (G-12) is a mouse monoclonal IgG1 κ Morc3 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 387-406 within an internal region of Morc3 of human origin
- Morc3 Antibody (G-12) is recommended for detection of Morc3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Morc3 Antibody (G-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Morc3 Antibody (G-12) for WB applications. This reagent is now offered in a bundle with Morc3 Antibody (G-12) (see ordering information below).
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Morc3 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Morc3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Morc3 (G-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The MORC family of proteins, which includes Morc3, consists of several members that play crucial roles in cellular processes; Morc3, also known as zinc finger CW-type coiled-coil domain protein 3 (ZCWCC3), is a 939 amino acid protein that is ubiquitously expressed in human cell lines and is localized to the nuclear matrix. This localization enables Morc3 to interact with key nuclear proteins, including p53 and SP-100, facilitating their recruitment to promyelocytic leukemia nuclear bodies. The interaction of Morc3 with these proteins is essential for the regulation of p53 activation, which is critical for maintaining genomic stability and responding to cellular stress. Anti-Morc3 antibody (G-12) enables researchers to explore the intricate roles of Morc3 in cellular signaling and its implications in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Morc3 Antibody (G-12) References:
- New gene family defined by MORC, a nuclear protein required for mouse spermatogenesis. | Inoue, N., et al. 1999. Hum Mol Genet. 8: 1201-7. PMID: 10369865
- Assignment of microrchidia (Morc) to mouse chromosome 16 by interspecific backcross linkage analysis and human chromosome 3q13 using somatic cell hybrids and in situ hybridization. | Inoue, N., et al. 2000. Cytogenet Cell Genet. 90: 123-5. PMID: 11060461
- The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. | Kimura, Y., et al. 2002. J Biol Chem. 277: 20611-7. PMID: 11927593
- Dynamic regulation of p53 subnuclear localization and senescence by MORC3. | Takahashi, K., et al. 2007. Mol Biol Cell. 18: 1701-9. PMID: 17332504
- MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. | Liggins, AP., et al. 2007. Br J Haematol. 138: 479-86. PMID: 17608765
- MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases. | Iyer, LM., et al. 2008. Biol Direct. 3: 8. PMID: 18346280
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. | Nagase, T., et al. 1995. DNA Res. 2: 167-74, 199-210. PMID: 8590280
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Morc3 Antibody (G-12) | sc-514672 | 200 µg/ml | $322.00 | |||
Morc3 Antibody (G-12): m-IgG Fc BP-HRP Bundle | sc-552124 | 200 µg Ab; 10 µg BP | $361.00 | |||
Morc3 Antibody (G-12) AC | sc-514672 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Morc3 Antibody (G-12) HRP | sc-514672 HRP | 200 µg/ml | $322.00 | |||
Morc3 Antibody (G-12) FITC | sc-514672 FITC | 200 µg/ml | $336.00 | |||
Morc3 Antibody (G-12) PE | sc-514672 PE | 200 µg/ml | $349.00 | |||
Morc3 Antibody (G-12) Alexa Fluor® 488 | sc-514672 AF488 | 200 µg/ml | $364.00 | |||
Morc3 Antibody (G-12) Alexa Fluor® 546 | sc-514672 AF546 | 200 µg/ml | $364.00 | |||
Morc3 Antibody (G-12) Alexa Fluor® 594 | sc-514672 AF594 | 200 µg/ml | $364.00 | |||
Morc3 Antibody (G-12) Alexa Fluor® 647 | sc-514672 AF647 | 200 µg/ml | $364.00 | |||
Morc3 Antibody (G-12) Alexa Fluor® 680 | sc-514672 AF680 | 200 µg/ml | $364.00 | |||
Morc3 Antibody (G-12) Alexa Fluor® 790 | sc-514672 AF790 | 200 µg/ml | $364.00 | |||
Morc3 (G-12) Neutralizing Peptide | sc-514672 P | 100 µg/0.5 ml | $69.00 |