MOCS2 Antibody (G-9): sc-377343

MOCS2 Antibody (G-9) is a mouse monoclonal IgG2b antibody that detects MOCS2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MOCS2, or molybdopterin synthase, plays a crucial role in the biosynthesis of molybdenum cofactor, specifically in the second step where MOCS2 catalyzes the conversion of precursor Z into molybdopterin by incorporating a dithiolene functional group. This process is vital as molybdopterin is an essential component of various molybdoenzymes, including aldehyde oxidase, xanthine dehydrogenase, and sulfite oxidase, which are critical for numerous biochemical reactions in the body. The proper functioning of these enzymes is necessary for the metabolism of purines and sulfur-containing compounds, highlighting the importance of MOCS2 in maintaining metabolic homeostasis. Notably, mutations in the MOCS2 gene can lead to molybdenum cofactor deficiency, a serious condition that can result in severe neurological impairment and early childhood mortality. Anti-MOCS2 antibody (G-9) is an invaluable tool for researchers studying the implications of MOCS2 in health and disease, providing insights into its role in enzymatic functions and potential therapeutic targets.

The preferred MOCS2 antibody is MOCS2 Antibody (F-9): sc-377169.