MOCS2 Antibody (F-9): sc-377169
- MOCS2 Antibody (F-9) is a mouse monoclonal IgG1 κ MOCS2 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-188 representing full length MOCS2 of human origin
- MOCS2 Antibody (F-9) is recommended for detection of MOCS2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MOCS2 Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MOCS2 Antibody (F-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with MOCS2 Antibody (F-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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MOCS2 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects MOCS2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MOCS2 (F-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MOCS2 protein, also known as molybdopterin synthase, plays a crucial role in the biosynthesis of molybdenum cofactor, specifically in the second step of synthesis where MOCS2 catalyzes the conversion of precursor Z into molybdopterin by incorporating a dithiolene functional group. This process is vital as molybdopterin is an essential component of several molybdoenzymes, including aldehyde oxidase, xanthine dehydrogenase, and sulfite oxidase, which are critical for various metabolic pathways. MOCS2 protein is a heterotetramer composed of two small (MOCS2A) and two large (MOCS2B) subunits, both encoded by a single bicistronic mRNA, highlighting the intricate regulation of expression. Notably, mutations in MOCS2 gene can lead to molybdenum cofactor deficiency, a serious condition that can result in severe neurological impairment and early childhood mortality, underscoring the importance of MOCS2 in human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MOCS2 Antibody (F-9) References:
- Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. | Reiss, J., et al. 1999. Am J Hum Genet. 64: 706-11. PMID: 10053004
- Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. | Rudolph, MJ., et al. 2003. J Biol Chem. 278: 14514-22. PMID: 12571227
- Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency. | Leimkuhler, S., et al. 2003. J Biol Chem. 278: 26127-34. PMID: 12732628
- Analysis of differentially expressed genes in nitric oxide-exposed human monocytic cells. | Turpaev, K., et al. 2005. Free Radic Biol Med. 38: 1392-400. PMID: 15855057
- Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase. | Leimkühler, S., et al. 2005. Hum Genet. 117: 565-70. PMID: 16021469
- Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1. | Singh, S., et al. 2005. Protein Sci. 14: 2095-102. PMID: 16046629
- A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase. | Hahnewald, R., et al. 2006. Mol Genet Metab. 89: 210-3. PMID: 16737835
- Molybdenum cofactor deficiency: clinical features in a Turkish patient. | Per, H., et al. 2007. Brain Dev. 29: 365-8. PMID: 17158010
- The maize viviparous15 locus encodes the molybdopterin synthase small subunit. | Suzuki, M., et al. 2006. Plant J. 45: 264-74. PMID: 16367969
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MOCS2 Antibody (F-9) | sc-377169 | 200 µg/ml | $316.00 | |||
MOCS2 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-523220 | 200 µg Ab, 40 µg BP | $354.00 | |||
MOCS2 Antibody (F-9) AC | sc-377169 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MOCS2 Antibody (F-9) HRP | sc-377169 HRP | 200 µg/ml | $316.00 | |||
MOCS2 Antibody (F-9) FITC | sc-377169 FITC | 200 µg/ml | $330.00 | |||
MOCS2 Antibody (F-9) PE | sc-377169 PE | 200 µg/ml | $343.00 | |||
MOCS2 Antibody (F-9) Alexa Fluor® 488 | sc-377169 AF488 | 200 µg/ml | $357.00 | |||
MOCS2 Antibody (F-9) Alexa Fluor® 546 | sc-377169 AF546 | 200 µg/ml | $357.00 | |||
MOCS2 Antibody (F-9) Alexa Fluor® 594 | sc-377169 AF594 | 200 µg/ml | $357.00 | |||
MOCS2 Antibody (F-9) Alexa Fluor® 647 | sc-377169 AF647 | 200 µg/ml | $357.00 | |||
MOCS2 Antibody (F-9) Alexa Fluor® 680 | sc-377169 AF680 | 200 µg/ml | $357.00 | |||
MOCS2 Antibody (F-9) Alexa Fluor® 790 | sc-377169 AF790 | 200 µg/ml | $357.00 |