MoCo Sulfurase Antibody (D-6): sc-398172
- MoCo Sulfurase Antibody (D-6) is a mouse monoclonal IgG2a κ MoCo Sulfurase antibody provided at 200 µg/ml
- raised against amino acids 359-485 mapping within an internal region of MoCo Sulfurase of human origin
- MoCo Sulfurase Antibody (D-6) is recommended for detection of MoCo Sulfurase of human origin by WB, IP, IF and ELISA
- Anti-MoCo Sulfurase Antibody (D-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MoCo Sulfurase Antibody (D-6) for WB applications. These reagents are now offered in bundles with MoCo Sulfurase Antibody (D-6) (see ordering information below).
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MoCo Sulfurase Antibody (D-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects MoCo Sulfurase of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MoCo Sulfurase antibody (D-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MoCo Sulfurase plays a crucial role in the biosynthesis of molybdenum cofactor, a vital component that activates molybdenum, a transitional metal essential for the catalytic activity of certain enzymes, including xanthine dehydrogenase and aldehyde oxidase. This enzyme, consisting of 888 amino acids, is responsible for the sulfuration of molybdenum cofactor, which is necessary for the proper functioning of these enzymes. Deficiencies in MoCo Sulfurase can lead to type II xanthinuria, a metabolic disorder characterized by excessive excretion of xanthine in urine and the formation of xanthine stones, which can cause significant health issues. Furthermore, individuals with type II xanthinuria are unable to effectively metabolize allopurinol into oxypurinol, resulting in decreased uric acid production and impaired purine synthesis. MoCo Sulfurase (D-6) antibody provides researchers with a valuable tool for studying the implications of MoCo Sulfurase in metabolic pathways and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MoCo Sulfurase Antibody (D-6) References:
- Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II. | Ichida, K., et al. 2001. Biochem Biophys Res Commun. 282: 1194-200. PMID: 11302742
- The absence of molybdenum cofactor sulfuration is the primary cause of the flacca phenotype in tomato plants. | Sagi, M., et al. 2002. Plant J. 31: 305-17. PMID: 12164810
- Mutations of the silkworm molybdenum cofactor sulfurase gene, og, cause translucent larval skin. | Kômoto, N., et al. 2003. Insect Biochem Mol Biol. 33: 417-27. PMID: 12650690
- Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II. | Yamamoto, T., et al. 2003. Metabolism. 52: 1501-4. PMID: 14624414
- The plant Mo-hydroxylases aldehyde oxidase and xanthine dehydrogenase have distinct reactive oxygen species signatures and are induced by drought and abscisic acid. | Yesbergenova, Z., et al. 2005. Plant J. 42: 862-76. PMID: 15941399
- Cell biology of molybdenum. | Mendel, RR. and Bittner, F. 2006. Biochim Biophys Acta. 1763: 621-35. PMID: 16784786
- Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria. | Peretz, H., et al. 2007. Mol Genet Metab. 91: 23-9. PMID: 17368066
- Metal ions in biological catalysis: from enzyme databases to general principles. | Andreini, C., et al. 2008. J Biol Inorg Chem. 13: 1205-18. PMID: 18604568
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MoCo Sulfurase Antibody (D-6) | sc-398172 | 200 µg/ml | $322.00 | |||
MoCo Sulfurase Antibody (D-6): m-IgG Fc BP-HRP Bundle | sc-530713 | 200 µg Ab; 10 µg BP | $361.00 | |||
MoCo Sulfurase Antibody (D-6): m-IgGκ BP-HRP Bundle | sc-524242 | 200 µg Ab, 40 µg BP | $361.00 | |||
MoCo Sulfurase Antibody (D-6): m-IgG2a BP-HRP Bundle | sc-547569 | 200 µg Ab; 10 µg BP | $361.00 | |||
MoCo Sulfurase Antibody (D-6) AC | sc-398172 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MoCo Sulfurase Antibody (D-6) HRP | sc-398172 HRP | 200 µg/ml | $322.00 | |||
MoCo Sulfurase Antibody (D-6) FITC | sc-398172 FITC | 200 µg/ml | $336.00 | |||
MoCo Sulfurase Antibody (D-6) PE | sc-398172 PE | 200 µg/ml | $349.00 | |||
MoCo Sulfurase Antibody (D-6) Alexa Fluor® 488 | sc-398172 AF488 | 200 µg/ml | $364.00 | |||
MoCo Sulfurase Antibody (D-6) Alexa Fluor® 546 | sc-398172 AF546 | 200 µg/ml | $364.00 | |||
MoCo Sulfurase Antibody (D-6) Alexa Fluor® 594 | sc-398172 AF594 | 200 µg/ml | $364.00 | |||
MoCo Sulfurase Antibody (D-6) Alexa Fluor® 647 | sc-398172 AF647 | 200 µg/ml | $364.00 | |||
MoCo Sulfurase Antibody (D-6) Alexa Fluor® 680 | sc-398172 AF680 | 200 µg/ml | $364.00 | |||
MoCo Sulfurase Antibody (D-6) Alexa Fluor® 790 | sc-398172 AF790 | 200 µg/ml | $364.00 |