Mnt Antibody (G-2): sc-376771

Mnt Antibody (G-2) is a mouse monoclonal IgG2a antibody that detects Mnt in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mnt, also known as MAD6, ROX, or MXD6, is a 582 amino acid nuclear protein that plays a crucial role in regulating gene expression by forming a complex with Max (Myc-associated factor X) to repress transcription. This interaction is vital for maintaining cellular homeostasis and preventing uncontrolled cell proliferation, which can lead to tumorigenesis. Mnt contains a basic helix-loop-helix (bHLH) domain, a structural motif that facilitates binding to Max and other transcription factors, thereby influencing various cellular processes, including differentiation and apoptosis. The gene encoding Mnt is located on human chromosome 17p13.3, a region that harbors important tumor suppressor genes such as p53 and BRCA1, both of which are integral to DNA repair mechanisms and the maintenance of genomic stability. Proper functioning of Mnt and interactions with other proteins are essential for preventing malignancies, making anti-Mnt antibody (G-2) a valuable tool for researchers studying cancer biology and transcriptional regulation.

The preferred Mnt antibody is Mnt Antibody (F-11): sc-376708.