MMP9 Antibody (7-11C): sc-13520

MMP-9 Antibody (7-11C) is a mouse monoclonal IgG1 kappa light chain antibody raised against partially purified human MMP-9, engineered to detect MMP-9 from mouse, rat, and human origins through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MMP-9 antibody (7-11C) is also available in multiple conjugated forms including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Matrix metalloproteinase-9 (MMP-9), also known as gelatinase B or 92 kDa type IV collagenase, is a pivotal enzyme within the matrix metalloproteinase (MMP) family, which plays a critical role in degrading extracellular matrix (ECM) components such as collagen, gelatin, fibronectin, laminin, and proteoglycans. MMP-9 is predominantly found extracellularly, secreted by various cell types including macrophages, neutrophils, and cancer cells. This extracellular presence enables tissue remodeling, wound healing, angiogenesis, and embryonic development by facilitating cell migration and invasion through ECM barrier breakdown. MMP-9 can also be found in the pericellular environment, interacting with cell surface receptors and other ECM molecules to regulate proteolytic activity. Extracellular MMP-9 is particularly significant in cancer metastasis, helping tumor cells invade surrounding tissues and enter the bloodstream, and in inflammatory diseases like rheumatoid arthritis, where excessive ECM degradation causes joint destruction. Understanding MMP-9′s specific location within cellular environments is crucial for studying both normal physiological processes and disease states, making anti-MMP-9 antibody (7-11C) valuable for investigating spatial dynamics and functional implications in various biological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MMP9 Antibody (7-11C) has 102 citations in a variety of scientific publications.

Primary antibodies like Anti-MMP9 Antibody (7-11C) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MMP9 Antibody (7-11C) Specifications

Alternate Product Name: MMP-9

Product Clone Name: 7-11C

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: MMP-9

Epitope Species: human

Product Reactivity/Detection: MMP-9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 102 citations in various scientific publications

Available Conjugates/Forms for MMP9 Antibody (7-11C): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, L: Azide-Free, PE: Phycoerythrin

The preferred MMP9 antibody is MMP9 Antibody (2C3): sc-21733.