MMP9 Antibody (6-6B): sc-12759
- MMP9 Antibody (6-6B) is a mouse monoclonal IgG1 κ, cited in 69 publications, provided at 200 µg/ml
- raised against partially purified human MMP-9
- MMP9 Antibody (6-6B) is recommended for detection of MMP-9 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MMP9 Antibody (6-6B) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for biological studies, sc-12759 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MMP9 Antibody (6-6B) for WB and IHC(P) applications. These reagents are now offered in bundles with MMP9 Antibody (6-6B) (see ordering information below).
MMP-9 Antibody (6-6B) is a mouse monoclonal IgG1 kappa light chain antibody raised against partially purified human MMP-9, designed for the detection of MMP-9 of human origin through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-MMP-9 antibody (6-6B) is available in multiple conjugated forms including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. Matrix metalloproteinase-9 (MMP-9), also known as 92 kDa type IV collagenase or gelatinase B, is a pivotal enzyme within the matrix metalloproteinase (MMP) family, which consists of zinc-dependent endopeptidases responsible for the degradation of extracellular matrix (ECM) components such as collagen, gelatin, fibronectin, laminin, and proteoglycans. MMP-9 plays crucial roles in normal physiological processes including tissue remodeling, wound healing, angiogenesis, and embryonic development, facilitating cell migration and invasion by breaking down ECM barriers. Beyond physiological roles, MMP-9 is significantly involved in various pathological conditions. MMP-9 overexpression and heightened activity are closely associated with cancer metastasis, promoting tumor invasion and dissemination by degrading basement membranes and ECM structures, thereby enabling cancer cells to penetrate surrounding tissues and enter the bloodstream. In inflammatory diseases like rheumatoid arthritis, MMP-9 contributes to joint destruction by degrading cartilage and bone matrix, leading to progressive tissue damage and loss of function. MMP-9 regulation occurs at multiple levels, including transcriptional activation by inflammatory cytokines and growth factors, as well as post-translational activation through proenzyme cleavage by other proteases. Understanding MMP-9 function is essential for developing targeted therapeutic strategies aimed at inhibiting activity to prevent disease progression and metastasis. MMP-9 (6-6B) monoclonal antibody is recommended for researchers investigating the molecular mechanisms of ECM remodeling, cancer progression, and inflammatory disease pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP9 Antibody (6-6B) | sc-12759 | 200 µg/ml | $322.00 | |||
MMP9 Antibody (6-6B): m-IgG Fc BP-HRP Bundle | sc-526537 | 200 µg Ab; 10 µg BP | $361.00 | |||
MMP9 Antibody (6-6B): m-IgG1 BP-HRP Bundle | sc-531910 | 200 µg Ab; 20 µg BP | $361.00 | |||
MMP9 Antibody (6-6B) L | sc-12759 L | 200 µg/0.1 ml | $322.00 | |||
MMP9 Antibody (6-6B) AC | sc-12759 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MMP9 Antibody (6-6B) HRP | sc-12759 HRP | 200 µg/ml | $322.00 | |||
MMP9 Antibody (6-6B) FITC | sc-12759 FITC | 200 µg/ml | $336.00 | |||
MMP9 Antibody (6-6B) PE | sc-12759 PE | 200 µg/ml | $349.00 | |||
MMP9 Antibody (6-6B) Alexa Fluor® 488 | sc-12759 AF488 | 200 µg/ml | $364.00 | |||
MMP9 Antibody (6-6B) Alexa Fluor® 546 | sc-12759 AF546 | 200 µg/ml | $364.00 | |||
MMP9 Antibody (6-6B) Alexa Fluor® 594 | sc-12759 AF594 | 200 µg/ml | $364.00 | |||
MMP9 Antibody (6-6B) Alexa Fluor® 647 | sc-12759 AF647 | 200 µg/ml | $364.00 | |||
MMP9 Antibody (6-6B) Alexa Fluor® 680 | sc-12759 AF680 | 200 µg/ml | $364.00 | |||
MMP9 Antibody (6-6B) Alexa Fluor® 790 | sc-12759 AF790 | 200 µg/ml | $364.00 |