MMP-8 Antibody (B-1): sc-514803

MMP-8 Antibody (B-1) is a mouse monoclonal IgM antibody that detects MMP-8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MMP-8 antibody (B-1) is available in a non-conjugated form, allowing for versatile experimental use. MMP-8, also known as neutrophil collagenase or collagenase-2, plays a crucial role in the degradation of fibrillar collagen types I, II, and III, which is essential for tissue remodeling and repair. MMP-8 is predominantly expressed in inflammatory conditions, highlighting its importance in processes such as wound healing and the postpartum involution of the uterus. Various stimuli influence MMP-8 expression, including phorbol ester and lipopolysaccharide, which activate gene transcription. MMP-8′s activity depends on calcium and zinc ions, which are critical for catalytic function. Understanding MMP-8 dynamics and interactions with other proteins involved in the extracellular matrix can provide insights into pathological conditions, making MMP-8 (B-1) antibody a valuable tool for researchers studying inflammation and tissue repair mechanisms.

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MMP-8 Antibody (B-1) References:

1. Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.  |  Hasty, KA., et al. 1990. J Biol Chem. 265: 11421-4. PMID: 2164002
2. The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes.  |  Luchian, I., et al. 2022. Int J Mol Sci. 23: PMID: 35163727
3. Immunoexpression of MMP-8 and MMP-9 in chronic subdural hematoma.  |  Su, GJ., et al. 2022. Front Neurol. 13: 988854. PMID: 36061997
4. Active MMP-8 as a Biomarker of Peri-implant Health or Disease.  |  Xanthopoulou, V., et al. 2023. Eur J Dent. 17: 924-928. PMID: 36063841
5. Circulating myeloid-derived MMP8 in stress susceptibility and depression.  |  Cathomas, F., et al. 2024. Nature. 626: 1108-1115. PMID: 38326622
6. Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis.  |  Zalewska, EA., et al. 2024. Int J Mol Sci. 25: PMID: 38473967
7. Exosomal miRNA-26b-5p from PRP suppresses NETs by targeting MMP-8 to promote diabetic wound healing.  |  Rui, S., et al. 2024. J Control Release. 372: 221-233. PMID: 38909697
8. Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.  |  Reinemer, P., et al. 1994. FEBS Lett. 338: 227-33. PMID: 8307185
9. Matrix metalloproteinases: a review.  |  Birkedal-Hansen, H., et al. 1993. Crit Rev Oral Biol Med. 4: 197-250. PMID: 8435466
10. Expression of several matrix metalloproteinase genes in human monocytic cells.  |  Machein, U. and Conca, W. 1997. Adv Exp Med Biol. 421: 247-51. PMID: 9330704
11. Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus.  |  Balbín, M., et al. 1998. J Biol Chem. 273: 23959-68. PMID: 9727011
12. MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers.  |  Nwomeh, BC., et al. 1999. J Surg Res. 81: 189-95. PMID: 9927539

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MMP-8 Antibody (B-1) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-MMP-8 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MMP-8 Antibody (B-1) Specifications

Alternate Product Name: MMP-8

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 122-166

Epitope Target: MMP-8

Epitope Species: human

Product Reactivity/Detection: MMP-8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for MMP-8 Antibody (B-1): N/A

The preferred MMP-1/8 antibody is MMP-1/8 Antibody (A-7): sc-137044.