MMP2 Antibody (2C1): sc-13594
- MMP2 Antibody (2C1) is a mouse monoclonal IgG1 κ MMP2 antibody, cited in 178 publications, provided at 200 µg/ml
- raised against the activated form of MMP-2 of human origin
- MMP2 Antibody (2C1) is recommended for detection of MMP-2 of mouse, rat and human origin by WB, IP and IF
- MMP2 Antibody (2C1) is available conjugated to agarose for IP; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MMP2 Antibody (2C1) for WB applications. These reagents are now offered in bundles with MMP2 Antibody (2C1) (see ordering information below).
MMP-2 Antibody (2C1) is a mouse monoclonal IgG1 kappa light chain antibody specifically engineered to detect the activated form of human MMP-2, as well as MMP-2 from mouse and rat origins across multiple applications including western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). MMP-2 monoclonal antibody (2C1) is raised against the activated form of MMP-2, ensuring precise binding to the target protein, and is available in both non-conjugated and various conjugated forms such as agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates to accommodate diverse experimental needs. Matrix metalloproteinase-2, also called MMP-2, gelatinase A, CLG4, MONA, CLG4A, and TBE-1, is a pivotal enzyme within the matrix metalloproteinase (MMP) family, which plays a crucial role in the degradation of extracellular matrix (ECM) components including collagen types IV, V, VII, and X, as well as gelatin type I. This enzymatic activity is essential for normal physiological processes such as tissue remodeling, angiogenesis, and wound healing, as well as pathological conditions like cancer metastasis, cardiovascular diseases, and inflammatory disorders. MMP-2 activity is tightly regulated by the Ras signaling pathway and requires both calcium and zinc ions for catalytic function. By cleaving ECM proteins, MMP-2 facilitates cellular migration and invasion, making MMP-2 a key player in tumor progression and metastasis. Additionally, MMP-2 is involved in the modulation of bioactive molecules within the ECM, influencing cell signaling pathways that govern cell proliferation, differentiation, and apoptosis. Understanding the expression and regulation of MMP-2 is vital for elucidating the mechanisms underlying various diseases, and anti-MMP-2 antibody (2C1) serves as an invaluable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MMP2 Antibody (2C1) References:
- Ras pathway is required for the activation of MMP-2 secretion and for the invasion of src-transformed 3Y1. | Thant, AA., et al. 1999. Oncogene. 18: 6555-63. PMID: 10597259
- Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16. | Huhtala, P., et al. 1990. Genomics. 6: 554-9. PMID: 2158484
- Structure of the human type IV collagenase gene. | Huhtala, P., et al. 1990. J Biol Chem. 265: 11077-82. PMID: 2162831
- H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. | Collier, IE., et al. 1988. J Biol Chem. 263: 6579-87. PMID: 2834383
- Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study. | Reinemer, P., et al. 1994. FEBS Lett. 338: 227-33. PMID: 8307185
- Matrix metalloproteinases: a review. | Birkedal-Hansen, H., et al. 1993. Crit Rev Oral Biol Med. 4: 197-250. PMID: 8435466
- Expression of several matrix metalloproteinase genes in human monocytic cells. | Machein, U. and Conca, W. 1997. Adv Exp Med Biol. 421: 247-51. PMID: 9330704
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MMP2 Antibody (2C1) | sc-13594 | 200 µg/ml | $322.00 | |||
MMP2 Antibody (2C1): m-IgG Fc BP-HRP Bundle | sc-526566 | 200 µg Ab; 10 µg BP | $361.00 | |||
MMP2 Antibody (2C1): m-IgG1 BP-HRP Bundle | sc-531939 | 200 µg Ab; 20 µg BP | $361.00 | |||
MMP2 Antibody (2C1) AC | sc-13594 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MMP2 Antibody (2C1) FITC | sc-13594 FITC | 200 µg/ml | $336.00 | |||
MMP2 Antibody (2C1) PE | sc-13594 PE | 200 µg/ml | $349.00 | |||
MMP2 Antibody (2C1) Alexa Fluor® 488 | sc-13594 AF488 | 200 µg/ml | $364.00 | |||
MMP2 Antibody (2C1) Alexa Fluor® 546 | sc-13594 AF546 | 200 µg/ml | $364.00 | |||
MMP2 Antibody (2C1) Alexa Fluor® 594 | sc-13594 AF594 | 200 µg/ml | $364.00 | |||
MMP2 Antibody (2C1) Alexa Fluor® 647 | sc-13594 AF647 | 200 µg/ml | $364.00 | |||
MMP2 Antibody (2C1) Alexa Fluor® 680 | sc-13594 AF680 | 200 µg/ml | $364.00 | |||
MMP2 Antibody (2C1) Alexa Fluor® 790 | sc-13594 AF790 | 200 µg/ml | $364.00 |