MLL2 Antibody (2E1): sc-293217

MLL2 Antibody (2E1) is a mouse monoclonal IgG2a kappa light chain antibody that detects MLL2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-MLL2 antibody (2E1) is available as a non-conjugated format. MLL2, also known as Lysine Methyltransferase 2D, plays a crucial role in gene expression regulation through function as a histone methyltransferase, specifically targeting histone H3 at lysine 4 (H3K4). This post-translational modification is vital for transcription activation and is implicated in various cellular processes, including development and differentiation. MLL2 is particularly important in mouse embryonic development, influencing adhesion-related cytoskeletal events that affect cell growth and survival. MLL2 gene is located at human locus 12q13.12, a region frequently associated with rearrangements or amplifications in solid tumors, highlighting significance in cancer biology. Additionally, MLL2 interacts with other members of mixed lineage leukemia gene family, such as MLL3 and MLL4, which associate with activating signal cointegrator-2 (ASC-2) to regulate H3K4 trimethylation and target gene expression. MLL2 and its interactions study is essential for understanding molecular mechanisms underlying various diseases, including leukemia and other malignancies.

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MLL2 Antibody (2E1) References:

1. MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.  |  Ruault, M., et al. 2002. Gene. 284: 73-81. PMID: 11891048
2. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.  |  Deng, LW., et al. 2004. Proc Natl Acad Sci U S A. 101: 757-62. PMID: 14718661
3. Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.  |  Lee, S., et al. 2006. Proc Natl Acad Sci U S A. 103: 15392-7. PMID: 17021013
4. Cross-talk between histone modifications in response to histone deacetylase inhibitors: MLL4 links histone H3 acetylation and histone H3K4 methylation.  |  Nightingale, KP., et al. 2007. J Biol Chem. 282: 4408-4416. PMID: 17166833
5. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.  |  Issaeva, I., et al. 2007. Mol Cell Biol. 27: 1889-903. PMID: 17178841
6. Increased apoptosis and skewed differentiation in mouse embryonic stem cells lacking the histone methyltransferase Mll2.  |  Lubitz, S., et al. 2007. Mol Biol Cell. 18: 2356-66. PMID: 17429066
7. Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.  |  Lee, S., et al. 2008. Mol Endocrinol. 22: 1312-9. PMID: 18372346

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MLL2 Antibody (2E1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-MLL2 Antibody (2E1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MLL2 Antibody (2E1) Specifications

Alternate Product Name: KMT2D

Product Clone Name: 2E1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1487-1586

Epitope Target: MLL2

Epitope Species: human

Product Reactivity/Detection: MLL2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for MLL2 Antibody (2E1): N/A