MIS Antibody (B-9): sc-365643
- MIS Antibody (B-9) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 27-51 at the N-terminus of MIS of mouse origin
- recommended for detection of precursor and mature MIS of mouse, rat and human origin by WB, IP, IF and ELISA
- See MIS (B-11): sc-166752 for MIS antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MIS Antibody (B-9) for WB applications. These reagents are now offered in bundles with MIS Antibody (B-9) (see ordering information below).
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MIS Antibody (B-9) is a mouse monoclonal IgG2a antibody that detects Mullerian inhibiting substance (MIS) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MIS antibody (B-9) plays a crucial role in the regulation of sexual differentiation during embryonic development, as MIS is produced by Sertoli cells in the fetal testis and is essential for male offspring development. MIS, along with testosterone, leads to the regression of the Mullerian ducts, which are precursors to female reproductive structures, while promoting the differentiation of the Wolffian ducts, which develop into male reproductive organs. This process is vital for proper sexual differentiation, and any defects in MIS can result in conditions such as persistent Mullerian duct syndrome type I (PMDS-1), a form of male pseudohermaphroditism characterized by the failure of Mullerian duct regression. MIS (B-9) antibody′s ability to detect MIS protein involved in inhibiting tumor growth derived from Mullerian duct tissues further underscores its importance in both developmental biology and potential therapeutic applications. Anti-MIS antibody (B-9) serves as an invaluable tool for researchers studying the intricate mechanisms of sexual differentiation and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MIS Antibody (B-9) References:
- Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. | Teixeira, J., et al. 2001. Endocr Rev. 22: 657-74. PMID: 11588147
- Enhanced purification and production of Müllerian inhibiting substance for therapeutic applications. | Donahoe, PK., et al. 2003. Mol Cell Endocrinol. 211: 37-42. PMID: 14656474
- Cellular localization of müllerian inhibiting substance messenger ribonucleic acid during human ovarian follicular development. | Whitman, GF. and Pantazis, CG. 1991. Am J Obstet Gynecol. 165: 1881-6. PMID: 1750488
- Mullerian inhibiting substance: a fetal hormone with surgical implications. | Hutson, JM., et al. 1985. Aust N Z J Surg. 55: 599-605. PMID: 2870703
- Quantification of Müllerian Inhibiting Substance/Anti-Müllerian Hormone polypeptide by isotope dilution mass spectrometry. | Whiting, G., et al. 2018. Anal Biochem. 560: 50-55. PMID: 29742446
- Expression of Müllerian-Inhibiting Substance/Anti-Müllerian Hormone Type II Receptor in the Human Theca Cells. | Cheon, KY., et al. 2018. J Clin Endocrinol Metab. 103: 3376-3385. PMID: 29947765
- Müllerian-Inhibiting Substance/Anti-Müllerian Hormone as a Predictor of Preterm Birth in Polycystic Ovary Syndrome. | Hsu, JY., et al. 2018. J Clin Endocrinol Metab. 103: 4187-4196. PMID: 30239805
- Functional profiles of Müllerian inhibiting substance/anti-Müllerian hormone (MIS/AMH) in primarily cultured endometrial cancer cells. | Kim, SI., et al. 2021. J Cancer. 12: 6289-6300. PMID: 34539902
- Breast cancer risk coordinators: Artificial intelligence-based density measurement and Mullerian-inhibiting substance. | Pedük, Ş., et al. 2023. Ir J Med Sci. 192: 1601-1606. PMID: 36229588
- New insights into mullerian inhibiting substance and its mechanism of action. | Lane, AH. and Donahoe, PK. 1998. J Endocrinol. 158: 1-6. PMID: 9713320
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MIS Antibody (B-9) | sc-365643 | 200 µg/ml | $316.00 | |||
MIS Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-535231 | 200 µg Ab; 40 µg BP | $354.00 | |||
MIS Antibody (B-9): m-IgG2a BP-HRP Bundle | sc-546216 | 200 µg Ab; 10 µg BP | $354.00 | |||
MIS (B-9) Neutralizing Peptide | sc-365643 P | 100 µg/0.5 ml | $68.00 |