MIP-T3 Antibody (F-1): sc-393753
- MIP-T3 Antibody (F-1) is a mouse monoclonal IgG2b κ MIP-T3 antibody provided at 200 µg/ml
- raised against amino acids 555-691 mapping at the C-terminus of MIP-T3 of human origin
- MIP-T3 Antibody (F-1) is recommended for detection of MIP-T3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MIP-T3 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MIP-T3 Antibody (F-1) for WB applications. These reagents are now offered in bundles with MIP-T3 Antibody (F-1) (see ordering information below).
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MIP-T3 Antibody (F-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects MIP-T3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MIP-T3 (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MIP-T3 protein plays a crucial role in regulating the cytoskeletal network by interacting with tumor necrosis factor receptor (TNFR) superfamily members and their downstream signaling pathways. Specifically, MIP-T3 binds to taxol-stabilized microtubules and tubulin, facilitating the recruitment of TNFR-associated factor 3 (TRAF3) to microtubules when both proteins are overexpressed. This interaction is mediated by the coiled-coil TRAF-N domain of TRAF3, which is essential for downstream signaling. The ability of MIP-T3 to sequester TRAF3 to the cytoskeletal network may provide a novel mechanism for regulating cellular responses such as proliferation, differentiation, and apoptosis, highlighting MIP-T3′s importance in maintaining cellular homeostasis and response to external stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MIP-T3 Antibody (F-1) References:
- MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network. | Ling, L. and Goeddel, DV. 2000. J Biol Chem. 275: 23852-60. PMID: 10791955
- DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation. | Morris, JA., et al. 2003. Hum Mol Genet. 12: 1591-608. PMID: 12812986
- MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation. | Niu, Y., et al. 2003. FEBS Lett. 550: 139-43. PMID: 12935900
- T3JAM, a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK(1). | Dadgostar, H., et al. 2003. FEBS Lett. 553: 403-7. PMID: 14572659
- Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder. | Kakiuchi, C., et al. 2007. Neurosci Lett. 417: 316-21. PMID: 17346882
- Caenorhabditis elegans DYF-11, an orthologue of mammalian Traf3ip1/MIP-T3, is required for sensory cilia formation. | Kunitomo, H. and Iino, Y. 2008. Genes Cells. 13: 13-25. PMID: 18173744
- An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes. | Li, C., et al. 2008. PLoS Genet. 4: e1000044. PMID: 18369462
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MIP-T3 Antibody (F-1) | sc-393753 | 200 µg/ml | $322.00 | |||
MIP-T3 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-524076 | 200 µg Ab, 40 µg BP | $361.00 | |||
MIP-T3 Antibody (F-1): m-IgG2b BP-HRP Bundle | sc-549151 | 200 µg Ab; 10 µg BP | $361.00 | |||
MIP-T3 Antibody (F-1) AC | sc-393753 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MIP-T3 Antibody (F-1) HRP | sc-393753 HRP | 200 µg/ml | $322.00 | |||
MIP-T3 Antibody (F-1) FITC | sc-393753 FITC | 200 µg/ml | $336.00 | |||
MIP-T3 Antibody (F-1) PE | sc-393753 PE | 200 µg/ml | $349.00 | |||
MIP-T3 Antibody (F-1) Alexa Fluor® 488 | sc-393753 AF488 | 200 µg/ml | $364.00 | |||
MIP-T3 Antibody (F-1) Alexa Fluor® 546 | sc-393753 AF546 | 200 µg/ml | $364.00 | |||
MIP-T3 Antibody (F-1) Alexa Fluor® 594 | sc-393753 AF594 | 200 µg/ml | $364.00 | |||
MIP-T3 Antibody (F-1) Alexa Fluor® 647 | sc-393753 AF647 | 200 µg/ml | $364.00 | |||
MIP-T3 Antibody (F-1) Alexa Fluor® 680 | sc-393753 AF680 | 200 µg/ml | $364.00 | |||
MIP-T3 Antibody (F-1) Alexa Fluor® 790 | sc-393753 AF790 | 200 µg/ml | $364.00 |