MIP-3α Antibody (C6): sc-517441

MIP-3α Antibody (C6) is a mouse monoclonal IgG1 kappa light chain antibody that detects the MIP-3 alpha protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-MIP-3α antibody (C6) is available as a non-conjugated format. MIP-3 alpha, also known as CCL20, plays a crucial role in the immune response by acting as a chemoattractant for lymphocytes and dendritic cells, particularly in the context of inflammatory responses and tissue homeostasis. MIP-3 alpha is primarily expressed in epithelial cells and is secreted in response to inflammatory stimuli, guiding immune cells to sites of infection or injury. MIP-3 alpha′s ability to attract specific immune cells is vital for initiating and regulating immune responses, making MIP-3 alpha an important target for research in immunology and potential therapeutic interventions. MIP-3 alpha interacts with the CCR6 receptor, which is predominantly expressed on T helper 17 (Th17) cells, further emphasizing MIP-3 alpha′s role in mediating inflammatory processes and influencing the development of autoimmune diseases.

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MIP-3α Antibody (C6) References:

1. Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter.  |  Reibman, J., et al. 2003. Am J Respir Cell Mol Biol. 28: 648-54. PMID: 12760962
2. Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.  |  Yang, D., et al. 2003. J Leukoc Biol. 74: 448-55. PMID: 12949249
3. MIP-3alpha/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection.  |  Woltman, AM., et al. 2005. Am J Transplant. 5: 2114-25. PMID: 16095490
4. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.  |  Zipfel, PF., et al. 1989. J Immunol. 142: 1582-90. PMID: 2521882
5. Investigation of proliferation and migration of tongue squamous cell carcinoma promoted by three chemokines, MIP-3α, MIP-1β, and IP-10.  |  Chu, H., et al. 2017. Onco Targets Ther. 10: 4193-4203. PMID: 28919775
6. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes.  |  Uguccioni, M., et al. 1995. Eur J Immunol. 25: 64-8. PMID: 7531149
7. Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes.  |  Schall, TJ., et al. 1993. J Exp Med. 177: 1821-6. PMID: 7684437
8. Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.  |  Widmer, U., et al. 1993. J Immunol. 150: 4996-5012. PMID: 8496601
9. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.  |  Cocchi, F., et al. 1995. Science. 270: 1811-5. PMID: 8525373
10. The role of MIP-1 alpha in inflammation and hematopoiesis.  |  Cook, DN. 1996. J Leukoc Biol. 59: 61-6. PMID: 8558069
11. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production.  |  Taub, DD., et al. 1996. J Leukoc Biol. 59: 81-9. PMID: 8558072
12. STRL22 is a receptor for the CC chemokine MIP-3alpha.  |  Liao, F., et al. 1997. Biochem Biophys Res Commun. 236: 212-7. PMID: 9223454

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MIP-3α Antibody (C6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-MIP-3α Antibody (C6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MIP-3α Antibody (C6) Specifications

Alternate Product Name: MIP-3α

Product Clone Name: C6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 27-96

Epitope Target: MIP-3α

Epitope Species: human

Product Reactivity/Detection: MIP-3α

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for MIP-3α Antibody (C6): N/A