MIP-3α Activators
MIP-3α activators encompass a diverse group of chemicals, primarily influencing the expression and activity of the chemokine MIP-3α (CCL20). This chemokine plays a significant role in immunological responses, particularly in attracting lymphocytes and dendritic cells to inflammation sites. The chemicals listed above can activate MIP-3α through various signaling pathways, predominantly through the NF-κB pathway, a key regulator in immune response and inflammation.
The chemical activators include both naturally occurring compounds like curcumin, resveratrol, and epigallocatechin gallate, and synthetic molecules like PMA and Poly(I:C). Lipopolysaccharide (LPS), a bacterial component, serves as a potent activator of immune responses and thereby MIP-3α expression. Similarly, cytokines such as TNF-α and IL-1β enhance MIP-3α expression as part of their role in mediating inflammatory responses. The involvement of these chemicals in upregulating MIP-3α is crucial for understanding inflammatory processes and immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS, a component of the outer membrane of Gram-negative bacteria, can induce MIP-3α expression in various cell types, particularly immune cells, by activating the NF-κB pathway. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA, a potent activator of Protein Kinase C (PKC), can induce MIP-3α expression in various cells, including epithelial cells. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin, an activator of adenylate cyclase, can indirectly enhance MIP-3α levels by increasing intracellular cAMP. | ||||||
Polyinosinic-polycytidylic acid potassium salt | 31852-29-6 | sc-202767 | 5 mg | $198.00 | ||
Polyinosinic-polycytidylic acid, a synthetic analog of double-stranded RNA, can stimulate MIP-3α production, especially in dendritic cells, through Toll-like receptor 3 (TLR3) activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a natural compound, can modulate MIP-3α expression, potentially through its effects on NF-κB and other signaling pathways. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 can regulate MIP-3α expression in various cells, including immune cells, via its receptor-mediated signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, can influence MIP-3α levels, likely through modulation of NF-κB and other related pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, can modulate MIP-3α expression, possibly through antioxidant and anti-inflammatory mechanisms. | ||||||