MIP-1α Antibody (E-2): sc-393899

MIP-1α Antibody (E-2) is a mouse monoclonal IgG2a antibody that detects MIP-1α in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MIP-1α, a member of the C-C chemokine subfamily, plays a crucial role in the immune response by acting as a potent chemoattractant for various immune cells, particularly CD4+ T lymphocytes. This selective attraction is vital for orchestrating an effective immune response, especially in the context of viral infections such as HIV. MIP-1α not only recruits immune cells to sites of inflammation but also has been identified as a significant HIV-suppressive factor produced by CD8+ T cells, working alongside MIP-1β and RANTES to inhibit HIV replication. The ability of MIP-1α to modulate immune cell trafficking and involvement in the control of HIV infection underscore its importance in both basic immunology and potential therapeutic applications. Anti-MIP-1α antibody (E-2) is an essential tool for researchers studying the dynamics of immune responses and the mechanisms of viral pathogenesis.

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MIP-1α Antibody (E-2) References:

1. MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines.  |  Dorner, BG., et al. 2002. Proc Natl Acad Sci U S A. 99: 6181-6. PMID: 11972057
2. CCL3/MIP-1alpha is a potent immunostimulator when coexpressed with interleukin-2 or granulocyte-macrophage colony-stimulating factor in a leukemia/lymphoma vaccine.  |  Zibert, A., et al. 2004. Hum Gene Ther. 15: 21-34. PMID: 14965375
3. Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease.  |  Man, SM., et al. 2007. Neurobiol Aging. 28: 485-96. PMID: 16600437
4. Therapeutic effect of MIP-1alpha-recruited dendritic cells on preestablished solid and metastatic tumors.  |  Cao, Q., et al. 2010. Cancer Lett. 295: 17-26. PMID: 20202744
5. Increased interictal serum levels of CXCL8/IL-8 and CCL3/MIP-1α in migraine.  |  Duarte, H., et al. 2015. Neurol Sci. 36: 203-8. PMID: 25190547
6. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration.  |  Guo, N., et al. 2015. Exp Lung Res. 41: 514-24. PMID: 26495959
7. The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory.  |  Marciniak, E., et al. 2015. Sci Rep. 5: 15862. PMID: 26511387
8. Macrophage inflammatory protein 1 alpha (MIP-1α) may be associated with poor outcome in patients with extranodal NK/T-cell lymphoma.  |  Kim, HS., et al. 2017. Hematol Oncol. 35: 310-316. PMID: 26928433
9. MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress.  |  Sindhu, S., et al. 2020. Cells. 9: PMID: 32751118
10. Myeloid-specific deletion of group VIA calcium-independent phospholipase A2 induces pro-inflammatory LPS response predominantly in male mice via MIP-1α activation.  |  Klement, L., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167016. PMID: 38198970

The preferred MIP-1α antibody is MIP-1α Antibody (D-3): sc-166942.