MIP-1α Antibody (D-3): sc-166942

MIP-1α Antibody (D-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects MIP-1α of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-MIP-1α antibody (D-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MIP-1α, a member of the C-C chemokine subfamily, plays a crucial role in the immune response by acting as a potent chemoattractant for monocytes and T cells, which are essential for mounting an effective immune defense. MIP-1α′s ability to attract CD8+ T lymphocytes is particularly significant, as these cells produce HIV-suppressive factors that can inhibit the replication of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). This function underscores MIP-1α′s importance in both innate and adaptive immune responses, particularly in viral infections. The diverse range of applications for MIP-1α (D-3) monoclonal antibody makes this reagent invaluable for researchers studying immune responses, chemokine signaling, and viral pathogenesis mechanisms.

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MIP-1α Antibody (D-3) References:

1. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity.  |  Lillard, JW., et al. 2003. Blood. 101: 807-14. PMID: 12393512
2. Mitogenic activation of human T cells induces two closely related genes which share structural similarities with a new family of secreted factors.  |  Zipfel, PF., et al. 1989. J Immunol. 142: 1582-90. PMID: 2521882
3. MIP-1α enhances Jurkat cell transendothelial migration by up-regulating endothelial adhesion molecules VCAM-1 and ICAM-1.  |  Ma, YR. and Ma, YH. 2014. Leuk Res. 38: 1327-31. PMID: 25245399
4. Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma.  |  Yang, MJ., et al. 2018. Cancer Commun (Lond). 38: 7. PMID: 29764502
5. MIP-1α and MCP-1 as salivary biomarkers in periodontal disease.  |  Nisha, KJ., et al. 2018. Saudi Dent J. 30: 292-298. PMID: 30202165
6. Associations between vaginal flora, MIP-1α, IL-17A, and clinical pregnancy rate in AIH.  |  Yang, H., et al. 2022. Am J Reprod Immunol. 88: e13543. PMID: 35357057
7. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes.  |  Uguccioni, M., et al. 1995. Eur J Immunol. 25: 64-8. PMID: 7531149
8. Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes.  |  Schall, TJ., et al. 1993. J Exp Med. 177: 1821-6. PMID: 7684437
9. Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.  |  Widmer, U., et al. 1993. J Immunol. 150: 4996-5012. PMID: 8496601
10. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.  |  Cocchi, F., et al. 1995. Science. 270: 1811-5. PMID: 8525373
11. The role of MIP-1 alpha in inflammation and hematopoiesis.  |  Cook, DN. 1996. J Leukoc Biol. 59: 61-6. PMID: 8558069
12. Beta chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production.  |  Taub, DD., et al. 1996. J Leukoc Biol. 59: 81-9. PMID: 8558072

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MIP-1α Antibody (D-3) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-MIP-1α Antibody (D-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MIP-1α Antibody (D-3) Specifications

Alternate Product Name: MIP-1α

Product Clone Name: D-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 77-92

Epitope Target: MIP-1α

Epitope Species: human

Product Reactivity/Detection: MIP-1α

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for MIP-1α Antibody (D-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin