MIP-1α Antibody (C-5): sc-365691
- MIP-1α Antibody (C-5) is a mouse monoclonal IgG1 λ MIP-1α antibody, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 67-92 at the C-terminus of MIP-1α of mouse origin
- MIP-1 alpha Antibody (C-5) is recommended for detection of MIP-1α of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
- Anti-MIP-1 alpha Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MIP-1α Antibody (C-5) for WB and IHC(P) applications. These reagents are now offered in bundles with MIP-1α Antibody (C-5) (see ordering information below).
MIP-1α Antibody (C-5) is a mouse monoclonal IgG1 antibody that detects MIP-1 alpha protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-MIP-1α antibody (C-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MIP-1α, a member of the C-C chemokine subfamily, plays a crucial role in the immune response by acting as a potent chemoattractant for monocytes and T cells, which are essential for mounting an effective immune defense. MIP-1α′s ability to attract CD8+ T lymphocytes is particularly significant, as these cells produce HIV-suppressive factors that can inhibit HIV infection. Research indicates that MIP-1α, along with MIP-1β and RANTES, is one of the major factors secreted by CD8+ T cells that contribute to the control of HIV, highlighting MIP-1α′s importance in both viral suppression and immune regulation. The diverse applications of MIP-1α monoclonal antibody (C-5) make this reagent an invaluable tool for researchers studying immune responses, chemokine signaling, and the mechanisms of viral infections.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MIP-1α Antibody (C-5) References:
- AML-1A and AML-1B regulation of MIP-1alpha expression in multiple myeloma. | Choi, SJ., et al. 2003. Blood. 101: 3778-83. PMID: 12560229
- MIP-3alpha and MIP-1alpha rapidly mobilize dendritic cell precursors into the peripheral blood. | He, S., et al. 2008. J Leukoc Biol. 84: 1549-56. PMID: 18791167
- CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain. | Kiguchi, N., et al. 2010. Neurosci Lett. 484: 17-21. PMID: 20692319
- Quercetin suppresses MIP-1α-induced adipose inflammation by downregulating its receptors CCR1/CCR5 and inhibiting inflammatory signaling. | Noh, HJ., et al. 2014. J Med Food. 17: 550-7. PMID: 24325454
- Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells. | Tsubaki, M., et al. 2016. Biomed Pharmacother. 78: 23-29. PMID: 26898421
- Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3. | Wang, Y., et al. 2016. Leukemia. 30: 1897-908. PMID: 27109512
- MIP-1α Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism. | Ahmad, R., et al. 2019. Cell Physiol Biochem. 52: 212-224. PMID: 30816669
- Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1α/CCR1 Pathway. | Li, M., et al. 2021. J Neuroimmune Pharmacol. 16: 318-333. PMID: 32301050
- Evaluation of IL-4, MIP-1α, and MMP-9 gene expression levels in peri-implant tissues in peri-implantitis. | Giro, G., et al. 2023. Braz Dent J. 34: 129-135. PMID: 37466520
- Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. | O'Grady, NP., et al. 1999. J Infect Dis. 179: 136-41. PMID: 9841832
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MIP-1α Antibody (C-5) | sc-365691 | 200 µg/ml | $316.00 | |||
MIP-1α Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-527391 | 200 µg Ab; 10 µg BP | $354.00 | |||
MIP-1α Antibody (C-5): m-IgG1 BP-HRP Bundle | sc-532764 | 200 µg Ab; 20 µg BP | $354.00 | |||
MIP-1α Antibody (C-5) AC | sc-365691 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MIP-1α Antibody (C-5) HRP | sc-365691 HRP | 200 µg/ml | $316.00 | |||
MIP-1α Antibody (C-5) FITC | sc-365691 FITC | 200 µg/ml | $330.00 | |||
MIP-1α Antibody (C-5) PE | sc-365691 PE | 200 µg/ml | $343.00 | |||
MIP-1α Antibody (C-5) Alexa Fluor® 488 | sc-365691 AF488 | 200 µg/ml | $357.00 | |||
MIP-1α Antibody (C-5) Alexa Fluor® 546 | sc-365691 AF546 | 200 µg/ml | $357.00 | |||
MIP-1α Antibody (C-5) Alexa Fluor® 594 | sc-365691 AF594 | 200 µg/ml | $357.00 | |||
MIP-1α Antibody (C-5) Alexa Fluor® 647 | sc-365691 AF647 | 200 µg/ml | $357.00 | |||
MIP-1α Antibody (C-5) Alexa Fluor® 680 | sc-365691 AF680 | 200 µg/ml | $357.00 | |||
MIP-1α Antibody (C-5) Alexa Fluor® 790 | sc-365691 AF790 | 200 µg/ml | $357.00 | |||
MIP-1α (C-5) Neutralizing Peptide | sc-365691 P | 100 µg/0.5 ml | $68.00 |