Mimitin Antibody (H-11): sc-365592

Mimitin Antibody (H-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Mimitin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Mimitin antibody (H-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mimitin, also known as Myc-induced mitochondrial protein (MMTN), is localized exclusively to the mitochondrion, which is crucial for its role in cellular metabolism and energy production. This localization allows Mimitin to participate in the regulation of mitochondrial function, particularly in the context of Myc-driven cellular processes. As a direct transcriptional target of c-Myc, Mimitin is involved in the modulation of gene expression that influences cell proliferation and survival, making Mimitin a significant player in oncogenic pathways. Notably, while Mimitin is highly expressed in esophageal squamous cell carcinoma (ESCC) cells, Mimitin expression does not correlate with the histopathological stage or grade of the cancer, suggesting a complex role in tumor biology.

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Mimitin Antibody (H-11) References:

1. Control of cell proliferation by Myc family genes.  |  Eilers, M. 1999. Mol Cells. 9: 1-6. PMID: 10102563
2. Gene transcription through Myc family members in eukaryotic cells.  |  Kuramoto, N., et al. 1999. Jpn J Pharmacol. 80: 103-9. PMID: 10440528
3. Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms.  |  Sugimoto, KJ., et al. 2002. Jpn J Cancer Res. 93: 1270-7. PMID: 12460470
4. A novel Myc-target gene, mimitin, that is involved in cell proliferation of esophageal squamous cell carcinoma.  |  Tsuneoka, M., et al. 2005. J Biol Chem. 280: 19977-85. PMID: 15774466
5. Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis.  |  Li, F., et al. 2005. Mol Cell Biol. 25: 6225-34. PMID: 15988031
6. Quantitative proteomic analysis of myc-induced apoptosis: a direct role for Myc induction of the mitochondrial chloride ion channel, mtCLIC/CLIC4.  |  Shiio, Y., et al. 2006. J Biol Chem. 281: 2750-6. PMID: 16316993
7. MYC family ties.  |  Schmidt, EV. 1996. Nat Genet. 14: 8-10. PMID: 8782810
8. Differential apoptotic behaviors of c-myc, N-myc, and L-myc oncoproteins.  |  Nesbit, CE., et al. 1998. Cell Growth Differ. 9: 731-41. PMID: 9751117

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mimitin Antibody (H-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Mimitin Antibody (H-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mimitin Antibody (H-11) Specifications

Alternate Product Name: Mimitin

Product Clone Name: H-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-169

Epitope Target: Mimitin

Epitope Species: human

Product Reactivity/Detection: Mimitin (Myc-induced mitochondrial protein)

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Mimitin Antibody (H-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin